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{{Infobox_gene}}
{{PBB_Controls
'''A-kinase anchor protein 13''' is an [[enzyme]] that in humans is encoded by the ''AKAP13'' [[gene]].<ref name="pmid9627117">{{cite journal | vauthors = Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, Pagliai K, Gray K, Gutkind S, Segars J | title = Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action | journal = Oncogene | volume = 16 | issue = 19 | pages = 2513–26  | date = Jul 1998 | pmid = 9627117 | pmc =  | doi = 10.1038/sj.onc.1201783 }}</ref><ref name="pmid1860836">{{cite journal | vauthors = Carr DW, Stofko-Hahn RE, Fraser ID, Bishop SM, Acott TS, Brennan RG, Scott JD | title = Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif | journal = J. Biol. Chem. | volume = 266 | issue = 22 | pages = 14188–92  | date = Sep 1991 | pmid = 1860836 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11214| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = A kinase (PRKA) anchor protein 13
| HGNCid = 371
| Symbol = AKAP13
| AltSymbols =; AKAP-Lbc; BRX; FLJ11952; FLJ43341; HA-3; Ht31; LBC; PROTO-LB; PROTO-LBC; c-lbc
| OMIM = 604686
| ECnumber = 
| Homologene = 4903
| MGIid = 2676556
| Function = {{GNF_GO|id=GO:0004691 |text = cAMP-dependent protein kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11214
    | Hs_Ensembl = ENSG00000170776
    | Hs_RefseqProtein = NP_006729
    | Hs_RefseqmRNA = NM_006738
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 83578821
    | Hs_GenLoc_end = 84093590
    | Hs_Uniprot = Q12802
    | Mm_EntrezGene = 75547
    | Mm_Ensembl = ENSMUSG00000066406
    | Mm_RefseqmRNA = XM_133543
    | Mm_RefseqProtein = XP_133543
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 75329069
    | Mm_GenLoc_end = 75610217
    | Mm_Uniprot = 
  }}
}}
'''A kinase (PRKA) anchor protein 13''', also known as '''AKAP13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11214| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a [[Pleckstrin homology domain|pleckstrin homology]] (PH) domain. The [[Guanine nucleotide exchange factor#DH and PH Domains|DH domain]] is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.<ref name="entrez">{{cite web | title = Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11214| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.<ref name="entrez">{{cite web | title = Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11214| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
AKAP13 has been shown to [[Protein-protein interaction|interact]] with [[Estrogen receptor alpha]],<ref name=pmid9627117 /> [[CTNNAL1]]<ref name=pmid12270917>{{cite journal | vauthors = Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D | title = Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45361–70  | date = Nov 2002 | pmid = 12270917 | doi = 10.1074/jbc.M202447200 }}</ref> and [[PRKAR2A]].<ref name=pmid12672969>{{cite journal | vauthors = Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD | title = Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 8 | pages = 4445–50  | date = Apr 2003 | pmid = 12672969 | pmc = 153575 | doi = 10.1073/pnas.0330734100 }}</ref><ref name=pmid1618839>{{cite journal | vauthors = Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD | title = Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain | journal = J. Biol. Chem. | volume = 267 | issue = 19 | pages = 13376–82  | date = Jul 1992 | pmid = 1618839 }}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|AKAP13}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD | title = Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain | journal = J. Biol. Chem. | volume = 267 | issue = 19 | pages = 13376–82 | year = 1992 | pmid = 1618839 | doi =  }}
| citations =
* {{cite journal | vauthors = Hausken ZE, Coghlan VM, Hastings CA, Reimann EM, Scott JD | title = Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5 | journal = J. Biol. Chem. | volume = 269 | issue = 39 | pages = 24245–51 | year = 1994 | pmid = 7929081 | doi =  }}
*{{cite journal | author=Carr DW, Hausken ZE, Fraser ID, ''et al.'' |title=Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. |journal=J. Biol. Chem. |volume=267 |issue= 19 |pages= 13376-82 |year= 1992 |pmid= 1618839 |doi=  }}
* {{cite journal | vauthors = Toksoz D, Williams DA | title = Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products | journal = Oncogene | volume = 9 | issue = 2 | pages = 621–8 | year = 1994 | pmid = 8290273 | doi =  }}
*{{cite journal | author=Carr DW, Stofko-Hahn RE, Fraser ID, ''et al.'' |title=Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14188-92 |year= 1991 |pmid= 1860836 |doi=  }}
* {{cite journal | vauthors = Sterpetti P, Hack AA, Bashar MP, Park B, Cheng SD, Knoll JH, Urano T, Feig LA, Toksoz D | title = Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting | journal = Mol. Cell. Biol. | volume = 19 | issue = 2 | pages = 1334–45 | year = 1999 | pmid = 9891067 | pmc = 116062 | doi =  }}
*{{cite journal | author=Hausken ZE, Coghlan VM, Hastings CA, ''et al.'' |title=Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5. |journal=J. Biol. Chem. |volume=269 |issue= 39 |pages= 24245-51 |year= 1994 |pmid= 7929081 |doi=  }}
* {{cite journal | vauthors = Sagi SA, Seasholtz TM, Kobiashvili M, Wilson BA, Toksoz D, Brown JH | title = Physical and functional interactions of Galphaq with Rho and its exchange factors | journal = J. Biol. Chem. | volume = 276 | issue = 18 | pages = 15445–52 | year = 2001 | pmid = 11278452 | pmc = 1761691 | doi = 10.1074/jbc.M008961200 }}
*{{cite journal | author=Toksoz D, Williams DA |title=Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. |journal=Oncogene |volume=9 |issue= 2 |pages= 621-8 |year= 1994 |pmid= 8290273 |doi=  }}
* {{cite journal | vauthors = Newlon MG, Roy M, Morikis D, Carr DW, Westphal R, Scott JD, Jennings PA | title = A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes | journal = EMBO J. | volume = 20 | issue = 7 | pages = 1651–62 | year = 2001 | pmid = 11285229 | pmc = 145475 | doi = 10.1093/emboj/20.7.1651 }}
*{{cite journal | author=Rubino D, Driggers P, Arbit D, ''et al.'' |title=Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. |journal=Oncogene |volume=16 |issue= 19 |pages= 2513-26 |year= 1998 |pmid= 9627117 |doi= 10.1038/sj.onc.1201783 }}
* {{cite journal | vauthors = Diviani D, Soderling J, Scott JD | title = AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation | journal = J. Biol. Chem. | volume = 276 | issue = 47 | pages = 44247–57 | year = 2001 | pmid = 11546812 | doi = 10.1074/jbc.M106629200 }}
*{{cite journal | author=Sterpetti P, Hack AA, Bashar MP, ''et al.'' |title=Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting. |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1334-45 |year= 1999 |pmid= 9891067 |doi= }}
* {{cite journal | vauthors = Driggers PH, Segars JH, Rubino DM | title = The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway | journal = J. Biol. Chem. | volume = 276 | issue = 50 | pages = 46792–7 | year = 2001 | pmid = 11579095 | pmc = 4152864 | doi = 10.1074/jbc.M106927200 }}
*{{cite journal  | author=Sagi SA, Seasholtz TM, Kobiashvili M, ''et al.'' |title=Physical and functional interactions of Galphaq with Rho and its exchange factors. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15445-52 |year= 2001 |pmid= 11278452 |doi= 10.1074/jbc.M008961200 }}
* {{cite journal | vauthors = Klussmann E, Edemir B, Pepperle B, Tamma G, Henn V, Klauschenz E, Hundsrucker C, Maric K, Rosenthal W | title = Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling | journal = FEBS Lett. | volume = 507 | issue = 3 | pages = 264–8 | year = 2001 | pmid = 11696353 | doi = 10.1016/S0014-5793(01)02995-7 }}
*{{cite journal  | author=Newlon MG, Roy M, Morikis D, ''et al.'' |title=A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1651-62 |year= 2001 |pmid= 11285229 |doi= 10.1093/emboj/20.7.1651 }}
* {{cite journal | vauthors = Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D | title = Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45361–70 | year = 2002 | pmid = 12270917 | doi = 10.1074/jbc.M202447200 }}
*{{cite journal | author=Diviani D, Soderling J, Scott JD |title=AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 44247-57 |year= 2001 |pmid= 11546812 |doi= 10.1074/jbc.M106629200 }}
* {{cite journal | vauthors = Tan YC, Wu H, Wang WN, Zheng Y, Wang ZX | title = Characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors | journal = Anal. Biochem. | volume = 310 | issue = 2 | pages = 156–62 | year = 2002 | pmid = 12423633 | doi = 10.1016/S0003-2697(02)00382-2 }}
*{{cite journal | author=Driggers PH, Segars JH, Rubino DM |title=The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 46792-7 |year= 2002 |pmid= 11579095 |doi= 10.1074/jbc.M106927200 }}
* {{cite journal | vauthors = Spierings E, Brickner AG, Caldwell JA, Zegveld S, Tatsis N, Blokland E, Pool J, Pierce RA, Mollah S, Shabanowitz J, Eisenlohr LC, van Veelen P, Ossendorp F, Hunt DF, Goulmy E, Engelhard VH | title = The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein | journal = Blood | volume = 102 | issue = 2 | pages = 621–9 | year = 2003 | pmid = 12663445 | doi = 10.1182/blood-2003-01-0260 }}
*{{cite journal | author=Klussmann E, Edemir B, Pepperle B, ''et al.'' |title=Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. |journal=FEBS Lett. |volume=507 |issue= 3 |pages= 264-8 |year= 2001 |pmid= 11696353 |doi= }}
* {{cite journal | vauthors = Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD | title = Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 8 | pages = 4445–50 | year = 2003 | pmid = 12672969 | pmc = 153575 | doi = 10.1073/pnas.0330734100 }}
*{{cite journal | author=Park B, Nguyen NT, Dutt P, ''et al.'' |title=Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45361-70 |year= 2003 |pmid= 12270917 |doi= 10.1074/jbc.M202447200 }}
* {{cite journal | vauthors = Hornemann T, Kempa S, Himmel M, Hayess K, Fürst DO, Wallimann T | title = Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein | journal = J. Mol. Biol. | volume = 332 | issue = 4 | pages = 877–87 | year = 2003 | pmid = 12972258 | doi = 10.1016/S0022-2836(03)00921-5 }}
*{{cite journal | author=Tan YC, Wu H, Wang WN, ''et al.'' |title=Characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors. |journal=Anal. Biochem. |volume=310 |issue= 2 |pages= 156-62 |year= 2003 |pmid= 12423633 |doi= }}
* {{cite journal | vauthors = Dutt P, Nguyen N, Toksoz D | title = Role of Lbc RhoGEF in Galpha12/13-induced signals to Rho GTPase | journal = Cell. Signal. | volume = 16 | issue = 2 | pages = 201–9 | year = 2004 | pmid = 14636890 | doi = 10.1016/S0898-6568(03)00132-3 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Chen LY, Zuraw BL, Ye RD, Pan ZK | title = A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytes | journal = J. Biol. Chem. | volume = 279 | issue = 8 | pages = 7208–12 | year = 2004 | pmid = 14660653 | doi = 10.1074/jbc.M309542200 }}
*{{cite journal | author=Spierings E, Brickner AG, Caldwell JA, ''et al.'' |title=The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein. |journal=Blood |volume=102 |issue= 2 |pages= 621-9 |year= 2003 |pmid= 12663445 |doi= 10.1182/blood-2003-01-0260 }}
*{{cite journal | author=Alto NM, Soderling SH, Hoshi N, ''et al.'' |title=Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4445-50 |year= 2003 |pmid= 12672969 |doi= 10.1073/pnas.0330734100 }}
*{{cite journal | author=Hornemann T, Kempa S, Himmel M, ''et al.'' |title=Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein. |journal=J. Mol. Biol. |volume=332 |issue= 4 |pages= 877-87 |year= 2003 |pmid= 12972258 |doi= }}
*{{cite journal  | author=Dutt P, Nguyen N, Toksoz D |title=Role of Lbc RhoGEF in Galpha12/13-induced signals to Rho GTPase. |journal=Cell. Signal. |volume=16 |issue= 2 |pages= 201-9 |year= 2004 |pmid= 14636890 |doi=  }}
*{{cite journal  | author=Chen LY, Zuraw BL, Ye RD, Pan ZK |title=A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytes. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 7208-12 |year= 2004 |pmid= 14660653 |doi= 10.1074/jbc.M309542200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{refend}}


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[[Category:A-kinase-anchoring proteins]]

Latest revision as of 17:54, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

A-kinase anchor protein 13 is an enzyme that in humans is encoded by the AKAP13 gene.[1][2][3]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.[3]

Interactions

AKAP13 has been shown to interact with Estrogen receptor alpha,[1] CTNNAL1[4] and PRKAR2A.[5][6]

References

  1. ↑ 1.0 1.1 Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, Pagliai K, Gray K, Gutkind S, Segars J (Jul 1998). "Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action". Oncogene. 16 (19): 2513–26. doi:10.1038/sj.onc.1201783. PMID 9627117.
  2. ↑ Carr DW, Stofko-Hahn RE, Fraser ID, Bishop SM, Acott TS, Brennan RG, Scott JD (Sep 1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". J. Biol. Chem. 266 (22): 14188–92. PMID 1860836.
  3. ↑ 3.0 3.1 "Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13".
  4. ↑ Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D (Nov 2002). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. 277 (47): 45361–70. doi:10.1074/jbc.M202447200. PMID 12270917.
  5. ↑ Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
  6. ↑ Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (Jul 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain". J. Biol. Chem. 267 (19): 13376–82. PMID 1618839.

External links

Further reading


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