AKAP10: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''A kinase anchor protein 10, mitochondrial''' is an [[enzyme]] that in humans is encoded by the ''AKAP10'' [[gene]].<ref name="pmid9326583">{{cite journal | vauthors = Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS | title = D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 21 | pages = 11184–9  | date = November 1997 | pmid = 9326583 | pmc = 23409 | doi = 10.1073/pnas.94.21.11184 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11216| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = A kinase (PRKA) anchor protein 10
| HGNCid = 368
| Symbol = AKAP10
| AltSymbols =; D-AKAP2; MGC9414; PRKA10
| OMIM = 604694
| ECnumber = 
| Homologene = 32452
| MGIid = 1890218
| GeneAtlas_image1 = PBB_GE_AKAP10_213396_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_AKAP10_205045_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008104 |text = protein localization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11216
    | Hs_Ensembl = ENSG00000108599
    | Hs_RefseqProtein = NP_009133
    | Hs_RefseqmRNA = NM_007202
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 19749344
    | Hs_GenLoc_end = 19821721
    | Hs_Uniprot = O43572
    | Mm_EntrezGene = 56697
    | Mm_Ensembl = ENSMUSG00000047804
    | Mm_RefseqmRNA = NM_019921
    | Mm_RefseqProtein = NP_064305
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 61687502
    | Mm_GenLoc_end = 61746447
    | Mm_Uniprot = Q3TR91
  }}
}}
'''A kinase (PRKA) anchor protein 10''', also known as '''AKAP10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11216| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.<ref name="entrez">{{cite web | title = Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11216| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
AKAP10 has been shown to [[Protein-protein interaction|interact]] with [[PDZK1]]<ref name=pmid14531806>{{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney Int. | volume = 64 | issue = 5 | pages = 1733–45  | date = November 2003 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x }}</ref> and [[PRKAR1A]].<ref name=pmid9326583 /><ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8  | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|AKAP10}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lester LB, Scott JD | title = Anchoring and scaffold proteins for kinases and phosphatases | journal = Recent Prog. Horm. Res. | volume = 52 | issue =  | pages = 409-29; discussion 429-30 | year = 1997 | pmid = 9238861 | doi =  }}
| citations =
* {{cite journal | vauthors = Michel JJ, Scott JD | title = AKAP mediated signal transduction | journal = Annu. Rev. Pharmacol. Toxicol. | volume = 42 | issue =  | pages = 235–57 | year = 2002 | pmid = 11807172 | doi = 10.1146/annurev.pharmtox.42.083101.135801 }}
*{{cite journal | author=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases. |journal=Recent Prog. Horm. Res. |volume=52 |issue=  |pages= 409-29; discussion 429-30 |year= 1997 |pmid= 9238861 |doi=  }}
* {{cite journal | vauthors = Epplen C, Epplen JT | title = Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes | journal = Hum. Genet. | volume = 93 | issue = 1 | pages = 35–41 | year = 1994 | pmid = 7505766 | doi = 10.1007/BF00218910 }}
*{{cite journal | author=Michel JJ, Scott JD |title=AKAP mediated signal transduction. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |issue=  |pages= 235-57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801 }}
* {{cite journal | vauthors = Wang L, Sunahara RK, Krumins A, Perkins G, Crochiere ML, Mackey M, Bell S, Ellisman MH, Taylor SS | title = Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 6 | pages = 3220–5 | year = 2001 | pmid = 11248059 | pmc = 30634 | doi = 10.1073/pnas.051633398 }}
*{{cite journal | author=Epplen C, Epplen JT |title=Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes. |journal=Hum. Genet. |volume=93 |issue= 1 |pages= 35-41 |year= 1994 |pmid= 7505766 |doi= }}
* {{cite journal | vauthors = Hamuro Y, Burns L, Canaves J, Hoffman R, Taylor S, Woods V | title = Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS) | journal = J. Mol. Biol. | volume = 321 | issue = 4 | pages = 703–14 | year = 2002 | pmid = 12206784 | doi = 10.1016/S0022-2836(02)00419-9 }}
*{{cite journal  | author=Huang LJ, Durick K, Weiner JA, ''et al.'' |title=D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11184-9 |year= 1997 |pmid= 9326583 |doi=  }}
* {{cite journal | vauthors = Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM, Nelson MR, Sing CF, Cantor CR, Taylor SS, Braun A | title = Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 7 | pages = 4066–71 | year = 2003 | pmid = 12646697 | pmc = 153049 | doi = 10.1073/pnas.2628028100 }}
*{{cite journal | author=Wang L, Sunahara RK, Krumins A, ''et al.'' |title=Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 6 |pages= 3220-5 |year= 2001 |pmid= 11248059 |doi= 10.1073/pnas.051633398 }}
* {{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney Int. | volume = 64 | issue = 5 | pages = 1733–45 | year = 2003 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x }}
*{{cite journal | author=Hamuro Y, Burns L, Canaves J, ''et al.'' |title=Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). |journal=J. Mol. Biol. |volume=321 |issue= 4 |pages= 703-14 |year= 2002 |pmid= 12206784 |doi= }}
* {{cite journal | vauthors = Burns-Hamuro LL, Barraclough DM, Taylor SS | title = Identification and functional analysis of dual-specific A kinase-anchoring protein-2 | journal = Meth. Enzymol. | volume = 390 | issue =  | pages = 354–74 | year = 2004 | pmid = 15488188 | doi = 10.1016/S0076-6879(04)90022-5 | isbn = 978-0-12-182795-3 | series = Methods in Enzymology }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Kammerer S, Burns-Hamuro LL, Ma Y, ''et al.'' |title=Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4066-71 |year= 2003 |pmid= 12646697 |doi= 10.1073/pnas.2628028100 }}
* {{cite journal | vauthors = Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan K, Kwok PY, Whooley MA, Conklin BR | title = Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 104 | issue = 20 | pages = 8461–6 | year = 2007 | pmid = 17485678 | pmc = 1866184 | doi = 10.1073/pnas.0610393104 }}
*{{cite journal | author=Gisler SM, Pribanic S, Bacic D, ''et al.'' |title=PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. |journal=Kidney Int. |volume=64 |issue= 5 |pages= 1733-45 |year= 2004 |pmid= 14531806 |doi= 10.1046/j.1523-1755.2003.00266.x }}
*{{cite journal | author=Burns-Hamuro LL, Barraclough DM, Taylor SS |title=Identification and functional analysis of dual-specific A kinase-anchoring protein-2. |journal=Meth. Enzymol. |volume=390 |issue=  |pages= 354-74 |year= 2005 |pmid= 15488188 |doi= 10.1016/S0076-6879(04)90022-5 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Tingley WG, Pawlikowska L, Zaroff JG, ''et al.'' |title=Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 20 |pages= 8461-6 |year= 2007 |pmid= 17485678 |doi= 10.1073/pnas.0610393104 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
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[[Category:A-kinase-anchoring proteins]]

Latest revision as of 02:32, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene.[1][2]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.[2]

Interactions

AKAP10 has been shown to interact with PDZK1[3] and PRKAR1A.[1][4]

References

  1. ↑ 1.0 1.1 Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS (November 1997). "D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11184–9. doi:10.1073/pnas.94.21.11184. PMC 23409. PMID 9326583.
  2. ↑ 2.0 2.1 "Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10".
  3. ↑ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
  4. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

Further reading


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