AIFM1

Apoptosis-inducing factor, mitochondrion-associated, 1
PDB rendering based on 1gv4.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1gv4​, 1m6i​
Identifiers
Symbols	AIFM1 ; AIF; MGC111425; PDCD8
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3100
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Apoptosis-inducing factor, mitochondrion-associated, 1, also known as AIFM1, is a human gene.

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Three alternative transcripts encoding different isoforms have been identified for this gene.

Further reading

• Daugas E, Nochy D, Ravagnan L; et al. (2000). "Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis". FEBS Lett. 476 (3): 118–23. PMID 10913597.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ferri KF, Jacotot E, Blanco J; et al. (2001). "Mitochondrial control of cell death induced by HIV-1-encoded proteins". Ann. N. Y. Acad. Sci. 926: 149–64. PMID 11193032.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Candé C, Cohen I, Daugas E; et al. (2002). "Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria". Biochimie. 84 (2–3): 215–22. PMID 12022952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Castedo M, Perfettini JL, Andreau K; et al. (2004). "Mitochondrial apoptosis induced by the HIV-1 envelope". Ann. N. Y. Acad. Sci. 1010: 19–28. PMID 15033690.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moon HS, Yang JS (2006). "Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells". Mol. Cells. 21 (1): 7–20. PMID 16511342.
• Glass L (1976). "Classification of biological networks by their qualitative dynamics". J. Theor. Biol. 54 (1): 85–107. PMID 1202295.
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Susin SA, Zamzami N, Castedo M; et al. (1997). "The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis". J. Exp. Med. 186 (1): 25–37. PMID 9206994.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Susin SA, Lorenzo HK, Zamzami N; et al. (1999). "Mitochondrial release of caspase-2 and -9 during the apoptotic process". J. Exp. Med. 189 (2): 381–94. PMID 9892620.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Susin SA, Lorenzo HK, Zamzami N; et al. (1999). "Molecular characterization of mitochondrial apoptosis-inducing factor". Nature. 397 (6718): 441–6. doi:10.1038/17135. PMID 9989411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Daugas E, Susin SA, Zamzami N; et al. (2000). "Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis". FASEB J. 14 (5): 729–39. PMID 10744629.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Joza N, Susin SA, Daugas E; et al. (2002). "Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death". Nature. 410 (6828): 549–54. doi:10.1038/35069004. PMID 11279485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ravagnan L, Gurbuxani S, Susin SA; et al. (2001). "Heat-shock protein 70 antagonizes apoptosis-inducing factor". Nat. Cell Biol. 3 (9): 839–43. doi:10.1038/ncb0901-839. PMID 11533664.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ye H, Cande C, Stephanou NC; et al. (2002). "DNA binding is required for the apoptogenic action of apoptosis inducing factor". Nat. Struct. Biol. 9 (9): 680–4. doi:10.1038/nsb836. PMID 12198487.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roumier T, Vieira HL, Castedo M; et al. (2003). "The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway". Cell Death Differ. 9 (11): 1212–9. doi:10.1038/sj.cdd.4401089. PMID 12404120.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)