AHA/ASA guideline recommendations for prevention of stroke in women overview: Difference between revisions

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====Hemorrhagic Stroke====
====Hemorrhagic Stroke====
There is an increased prevalence of [[subarachnoid hemorrhage]] in women,<ref name="pmid18162891">{{cite journal| author=Shea AM, Reed SD, Curtis LH, Alexander MJ, Villani JJ, Schulman KA| title=Characteristics of nontraumatic subarachnoid hemorrhage in the United States in 2003. | journal=Neurosurgery | year= 2007 | volume= 61 | issue= 6 | pages= 1131-7; discussion 1137-8 | pmid=18162891 | doi=10.1227/01.neu.0000306090.30517.ae | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18162891  }} </ref><ref name="pmid19571544">{{cite journal| author=Sacco S, Totaro R, Toni D, Marini C, Cerone D, Carolei A| title=Incidence, case-fatalities and 10-year survival of subarachnoid hemorrhage in a population-based registry. | journal=Eur Neurol | year= 2009 | volume= 62 | issue= 3 | pages= 155-60 | pmid=19571544 | doi=10.1159/000226617 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19571544  }} </ref> which has been linked to an increased prevalence of [[cerebral aneurysms]].<ref name="pmid10648430">{{cite journal| author=Wardlaw JM, White PM| title=The detection and management of unruptured intracranial aneurysms. | journal=Brain | year= 2000 | volume= 123 ( Pt 2) | issue=  | pages= 205-21 | pmid=10648430 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10648430  }} </ref>  Conversely, the incidence of [[intracerebral hemorrhage]], in most cases, has been reported to be lower in women when compared with men.<ref name="pmid11032611">{{cite journal| author=Nilsson OG, Lindgren A, Ståhl N, Brandt L, Säveland H| title=Incidence of intracerebral and subarachnoid haemorrhage in southern Sweden. | journal=J Neurol Neurosurg Psychiatry | year= 2000 | volume= 69 | issue= 5 | pages= 601-7 | pmid=11032611 | doi= | pmc=PMC1763383 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11032611  }} </ref>  The highest incidence of ICH was also observed among the black population as compared with hispanics and white population.
There is an increased prevalence of [[subarachnoid hemorrhage]] in women,<ref name="pmid18162891">{{cite journal| author=Shea AM, Reed SD, Curtis LH, Alexander MJ, Villani JJ, Schulman KA| title=Characteristics of nontraumatic subarachnoid hemorrhage in the United States in 2003. | journal=Neurosurgery | year= 2007 | volume= 61 | issue= 6 | pages= 1131-7; discussion 1137-8 | pmid=18162891 | doi=10.1227/01.neu.0000306090.30517.ae | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18162891  }} </ref><ref name="pmid19571544">{{cite journal| author=Sacco S, Totaro R, Toni D, Marini C, Cerone D, Carolei A| title=Incidence, case-fatalities and 10-year survival of subarachnoid hemorrhage in a population-based registry. | journal=Eur Neurol | year= 2009 | volume= 62 | issue= 3 | pages= 155-60 | pmid=19571544 | doi=10.1159/000226617 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19571544  }} </ref> which has been linked to an increased prevalence of [[cerebral aneurysms]].<ref name="pmid10648430">{{cite journal| author=Wardlaw JM, White PM| title=The detection and management of unruptured intracranial aneurysms. | journal=Brain | year= 2000 | volume= 123 ( Pt 2) | issue=  | pages= 205-21 | pmid=10648430 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10648430  }} </ref>  Conversely, the incidence of [[intracerebral hemorrhage]], in most cases, has been reported to be lower in women when compared with men.<ref name="pmid11032611">{{cite journal| author=Nilsson OG, Lindgren A, Ståhl N, Brandt L, Säveland H| title=Incidence of intracerebral and subarachnoid haemorrhage in southern Sweden. | journal=J Neurol Neurosurg Psychiatry | year= 2000 | volume= 69 | issue= 5 | pages= 601-7 | pmid=11032611 | doi= | pmc=PMC1763383 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11032611  }} </ref>  The highest incidence of ICH was also observed among the black population as compared with hispanics and white population.
==Risk Factors==
{| Class="wikitable"
!Sex-specific
!Stronger or commoner in women
|-
|[[Pregnancy]]
|[[Migraine|Migraine with aura]]
|-
|[[Preeclampsia]]
|[[Atrial fibrillation]]
|-
|[[Gestational diabetes]]
|Diabetes mellitus]]
|-
|[[Oral contraceptive]]s
|[[Hypertension]]
|-
|Hypertensive emergency with ARF/CRF
|Nicardipine or fenoldopam
|-
|Hypertensive encephalopathy
|Nicardipine, labetalol, fenoldopam <br> Note: The BP should not be lowered by more than 25%
|-
|Pre-eclampsia/eclampsia
|Labetalol or nicardipine
|-
|Sympathetic crisis/cocaine overdose
|Benzodiazepine + (verapamil, diltiazem, or nicardipine) <br> Note: Beta blockers should '''NOT''' be administered alone to prevent un-opposed alpha-adrenergic stimulation
|-
|Cerebrovascular accident
|Nicardipine, labetalol, fenoldopam, or clevidipine <br> Note: An expert's judgement is required to determine if the BP should be lowered.
|-
|Withdrawal of antihypertensive therapy e.g. clonidine or propanolol
|Re-administer the discontinued drug;  phentolamine, nitroprusside, or labetalol, if necessary
|}


==References==
==References==

Revision as of 21:18, 11 February 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ayokunle Olubaniyi, M.B,B.S [2]

Overview

The incidence of stroke, especially in women, is fast-rising. Stroke is the third leading cause of death in women and fifth in men.[1] Many studies have documented the fact that women are more adversely affected by stroke and its complications, in terms of functional recovery, quality of life when compared to men.[2][3][4] Therefore, it is important to provide guidelines to identify high-risk women for stroke, and also to provide recommendations regarding prevention of stroke.

Epidemioloogy and Dermographics

Ischemic Stroke

In general, women have a lower incidence of ischemic stroke than men. Women have a longer life expectancy than men, therefore, at ages 85 years and older, women have a higher[5] or similar incidences of stroke with men.[6] A population-based incidence study also noted a ≥2-fold increase in stroke incidence among blacks and Hispanics when compared with whites.[7]

Hemorrhagic Stroke

There is an increased prevalence of subarachnoid hemorrhage in women,[8][9] which has been linked to an increased prevalence of cerebral aneurysms.[10] Conversely, the incidence of intracerebral hemorrhage, in most cases, has been reported to be lower in women when compared with men.[11] The highest incidence of ICH was also observed among the black population as compared with hispanics and white population.

Risk Factors

Sex-specific Stronger or commoner in women
Pregnancy Migraine with aura
Preeclampsia Atrial fibrillation
Gestational diabetes Diabetes mellitus]]
Oral contraceptives Hypertension
Hypertensive emergency with ARF/CRF Nicardipine or fenoldopam
Hypertensive encephalopathy Nicardipine, labetalol, fenoldopam
Note: The BP should not be lowered by more than 25%
Pre-eclampsia/eclampsia Labetalol or nicardipine
Sympathetic crisis/cocaine overdose Benzodiazepine + (verapamil, diltiazem, or nicardipine)
Note: Beta blockers should NOT be administered alone to prevent un-opposed alpha-adrenergic stimulation
Cerebrovascular accident Nicardipine, labetalol, fenoldopam, or clevidipine
Note: An expert's judgement is required to determine if the BP should be lowered.
Withdrawal of antihypertensive therapy e.g. clonidine or propanolol Re-administer the discontinued drug; phentolamine, nitroprusside, or labetalol, if necessary

References

  1. "Products - Health United States - Tables - 2011 Complete List". Retrieved 11 February 2014.
  2. Gall, SL.; Tran, PL.; Martin, K.; Blizzard, L.; Srikanth, V. (2012). "Sex differences in long-term outcomes after stroke: functional outcomes, handicap, and quality of life". Stroke. 43 (7): 1982–7. doi:10.1161/STROKEAHA.111.632547. PMID 22569940. Unknown parameter |month= ignored (help)
  3. Gargano, JW.; Reeves, MJ. (2007). "Sex differences in stroke recovery and stroke-specific quality of life: results from a statewide stroke registry". Stroke. 38 (9): 2541–8. doi:10.1161/STROKEAHA.107.485482. PMID 17673706. Unknown parameter |month= ignored (help)
  4. Kim, JS.; Lee, KB.; Roh, H.; Ahn, MY.; Hwang, HW. (2010). "Gender differences in the functional recovery after acute stroke". J Clin Neurol. 6 (4): 183–8. doi:10.3988/jcn.2010.6.4.183. PMID 21264198. Unknown parameter |month= ignored (help)
  5. Petrea RE, Beiser AS, Seshadri S, Kelly-Hayes M, Kase CS, Wolf PA (2009). "Gender differences in stroke incidence and poststroke disability in the Framingham heart study". Stroke. 40 (4): 1032–7. doi:10.1161/STROKEAHA.108.542894. PMC 2676725. PMID 19211484.
  6. Appelros P, Stegmayr B, Terént A (2009). "Sex differences in stroke epidemiology: a systematic review". Stroke. 40 (4): 1082–90. doi:10.1161/STROKEAHA.108.540781. PMID 19211488.
  7. Sacco RL, Boden-Albala B, Gan R, Chen X, Kargman DE, Shea S; et al. (1998). "Stroke incidence among white, black, and Hispanic residents of an urban community: the Northern Manhattan Stroke Study". Am J Epidemiol. 147 (3): 259–68. PMID 9482500.
  8. Shea AM, Reed SD, Curtis LH, Alexander MJ, Villani JJ, Schulman KA (2007). "Characteristics of nontraumatic subarachnoid hemorrhage in the United States in 2003". Neurosurgery. 61 (6): 1131–7, discussion 1137-8. doi:10.1227/01.neu.0000306090.30517.ae. PMID 18162891.
  9. Sacco S, Totaro R, Toni D, Marini C, Cerone D, Carolei A (2009). "Incidence, case-fatalities and 10-year survival of subarachnoid hemorrhage in a population-based registry". Eur Neurol. 62 (3): 155–60. doi:10.1159/000226617. PMID 19571544.
  10. Wardlaw JM, White PM (2000). "The detection and management of unruptured intracranial aneurysms". Brain. 123 ( Pt 2): 205–21. PMID 10648430.
  11. Nilsson OG, Lindgren A, Ståhl N, Brandt L, Säveland H (2000). "Incidence of intracerebral and subarachnoid haemorrhage in southern Sweden". J Neurol Neurosurg Psychiatry. 69 (5): 601–7. PMC 1763383. PMID 11032611.

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