ADCY3
| Adenylate cyclase 3 | |||||||||||
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| Symbols | ADCY3 ; AC3; KIAA0511 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2978 | ||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
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Adenylate cyclase 3, also known as ADCY3, is a human gene.[1]
This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes.[1]
References
Further reading
- Gaudin C, Homcy CJ, Ishikawa Y (1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Hum. Genet. 94 (5): 527–9. PMID 7959689.
- Haber N, Stengel D, Defer N; et al. (1994). "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI". Hum. Genet. 94 (1): 69–73. PMID 8034296.
- Hellevuo K, Yoshimura M, Kao M; et al. (1993). "A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line". Biochem. Biophys. Res. Commun. 192 (1): 311–8. doi:10.1006/bbrc.1993.1415. PMID 8476432.
- Wei J, Wayman G, Storm DR (1996). "Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo". J. Biol. Chem. 271 (39): 24231–5. PMID 8798667.
- Nagase T, Ishikawa K, Miyajima N; et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. PMID 9628581.
- Wei J, Zhao AZ, Chan GC; et al. (1998). "Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals". Neuron. 21 (3): 495–504. PMID 9768837.
- Yang B, He B, Abdel-Halim SM; et al. (1999). "Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets". Biochem. Biophys. Res. Commun. 254 (3): 548–51. doi:10.1006/bbrc.1998.9983. PMID 9920776.
- Barcova M, Speth C, Kacani L; et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflugers Arch. 437 (4): 538–46. PMID 10089566.
- Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. PMID 10807185.
- Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
- Vanvooren V, Allgeier A, Cosson E; et al. (2001). "Expression of multiple adenylyl cyclase isoforms in human and dog thyroid". Mol. Cell. Endocrinol. 170 (1–2): 185–96. PMID 11162902.
- Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. PMID 11299302.
- Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. PMID 11549699.
- Speth C, Schabetsberger T, Mohsenipour I; et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". J. Virol. 76 (7): 3179–88. PMID 11884542.
- Kobayakawa K, Hayashi R, Morita K; et al. (2002). "Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons". J. Neurosci. 22 (14): 5931–7. PMID 12122055.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. PMID 12503609.
- Katsel PL, Tagliente TM, Schwarz TE; et al. (2003). "Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets". Platelets. 14 (1): 21–33. PMID 12623444.
- Celano M, Arturi F, Presta I; et al. (2004). "Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules". Mol. Cell. Endocrinol. 203 (1–2): 129–35. PMID 12782409.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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