ADAM33

ADAM metallopeptidase domain 33
PDB rendering based on 1r54.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1r54​, 1r55​
Identifiers
Symbols	ADAM33 ; DJ964F7.1; DKFZp434K0521; FLJ35308; FLJ36751; MGC149823; MGC71889
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11881
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ADAM metallopeptidase domain 33, also known as ADAM33, is a human gene.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Further reading

• Holgate ST, Davies DE, Rorke S; et al. (2005). "ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma". Clinical reviews in allergy & immunology. 27 (1): 23–34. PMID 15347848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holloway JW, Davies DE, Powell R; et al. (2007). "The discovery and role of ADAM33, a new candidate gene for asthma". Expert reviews in molecular medicine. 6 (17): 1–12. doi:10.1017/S1462399404007963. PMID 15387895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holgate ST, Yang Y, Haitchi HM; et al. (2006). "The genetics of asthma: ADAM33 as an example of a susceptibility gene". Proceedings of the American Thoracic Society. 3 (5): 440–3. doi:10.1513/pats.200603-026AW. PMID 16799089.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshinaka T, Nishii K, Yamada K; et al. (2002). "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity". Gene. 282 (1–2): 227–36. PMID 11814695.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Van Eerdewegh P, Little RD, Dupuis J; et al. (2002). "Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness". Nature. 418 (6896): 426–30. doi:10.1038/nature00878. PMID 12110844.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Garlisi CG, Zou J, Devito KE; et al. (2003). "Human ADAM33: protein maturation and localization". Biochem. Biophys. Res. Commun. 301 (1): 35–43. PMID 12535637.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chae SC, Yoon KH, Chung HT (2003). "Identification of novel polymorphisms in the Adam33 gene". J. Hum. Genet. 48 (5): 278–81. doi:10.1007/s10038-003-0019-1. PMID 12768445.CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Howard TD, Postma DS, Jongepier H; et al. (2003). "Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations". J. Allergy Clin. Immunol. 112 (4): 717–22. doi:10.1016/S0091. PMID 14564349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Orth P, Reichert P, Wang W; et al. (2004). "Crystal structure of the catalytic domain of human ADAM33". J. Mol. Biol. 335 (1): 129–37. PMID 14659745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zou J, Zhu F, Liu J; et al. (2004). "Catalytic activity of human ADAM33". J. Biol. Chem. 279 (11): 9818–30. doi:10.1074/jbc.M309696200. PMID 14676211.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Powell RM, Wicks J, Holloway JW; et al. (2004). "The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts". Am. J. Respir. Cell Mol. Biol. 31 (1): 13–21. doi:10.1165/rcmb.2003-0330OC. PMID 14742294.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haitchi HM, Powell RM, Shaw TJ; et al. (2005). "ADAM33 expression in asthmatic airways and human embryonic lungs". Am. J. Respir. Crit. Care Med. 171 (9): 958–65. doi:10.1164/rccm.200409-1251OC. PMID 15709049.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zou J, Zhang R, Zhu F; et al. (2005). "ADAM33 enzyme properties and substrate specificity". Biochemistry. 44 (11): 4247–56. doi:10.1021/bi0476230. PMID 15766253.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simpson A, Maniatis N, Jury F; et al. (2005). "Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function". Am. J. Respir. Crit. Care Med. 172 (1): 55–60. doi:10.1164/rccm.200412-1708OC. PMID 15805180.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)