ADAM2

ADAM metallopeptidase domain 2 (fertilin beta)
Identifiers
Symbols	ADAM2 ; CRYN1; CRYN2; FTNB; PH-30b; PH30
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1127
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ADAM metallopeptidase domain 2 (fertilin beta), also known as ADAM2, is a human gene.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.

Further reading

• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eto K, Huet C, Tarui T; et al. (2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions". J. Biol. Chem. 277 (20): 17804–10. doi:10.1074/jbc.M200086200. PMID 11882657.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikawa M, Nakanishi T, Yamada S; et al. (2002). "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility". Dev. Biol. 240 (1): 254–61. doi:10.1006/dbio.2001.0462. PMID 11784061.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cho C, Ge H, Branciforte D; et al. (2000). "Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion". Dev. Biol. 222 (2): 289–95. doi:10.1006/dbio.2000.9703. PMID 10837118.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen MS, Tung KS, Coonrod SA; et al. (1999). "Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11830–5. PMID 10518536.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, Sampson NS (1999). "Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta". Chem. Biol. 6 (1): 1–10. doi:10.1016/S1074-5521(99)80015-5. PMID 9889149.
• Burkin HR, Burkin DJ, Davey PM; et al. (1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics. 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vidaeus CM, von Kapp-Herr C, Golden WL; et al. (1997). "Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member". Mol. Reprod. Dev. 46 (3): 363–9. doi:10.1002/(SICI)1098-2795(199703)46:3<363::AID-MRD15>3.0.CO;2-#. PMID 9041139.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gupta SK, Alves K, Palladino LO; et al. (1996). "Molecular cloning of the human fertilin beta subunit". Biochem. Biophys. Res. Commun. 224 (2): 318–26. doi:10.1006/bbrc.1996.1027. PMID 8702389.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. PMID 1602151.