ACTG1

Actin, gamma 1
File:PBB Protein ACTG1 image.jpg PDB rendering based on 1atn.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1atn​, 1c0f​, 1c0g​, 1d4x​, 1dej​, 1eqy​, 1esv​, 1h1v​, 1hlu​, 1ijj​, 1j6z​, 1kxp​, 1lcu​, 1lot​, 1m8q​, 1ma9​, 1mdu​, 1mvw​, 1nlv​, 1nm1​, 1nmd​, 1nwk​, 1o18​, 1o19​, 1o1a​, 1o1b​, 1o1c​, 1o1d​, 1o1e​, 1o1f​, 1o1g​, 1p8z​, 1qz5​, 1qz6​, 1rdw​, 1rfq​, 1rgi​, 1s22​, 1sqk​, 1t44​, 1wua​, 1y64​, 1yxq​, 2a3z​, 2a40​, 2a41​, 2a42​, 2a5x​, 2asm​, 2aso​, 2asp​, 2btf​, 2d1k​, 2ff3​, 2ff6​, 2fxu​, 2gwj​, 2gwk​, 2hf3​, 2hf4​, 2hmp​, 2oan​, 2q1n​, 2q31​, 2q36​
Identifiers
Symbols	ACTG1 ; ACT; ACTG; DFNA20; DFNA26
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74402
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Actin, gamma 1, also known as ACTG1, is a gene.

Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in nonmuscle cells.

See also

• Actin

Further reading

• Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biol. (Praha). 42 (5): 227–30. PMID 8997639.
• Rodríguez Del Castillo A, Vitale ML, Trifaró JM (1992). "Ca2+ and pH determine the interaction of chromaffin cell scinderin with phosphatidylserine and phosphatidylinositol 4,5,-biphosphate and its cellular distribution during nicotinic-receptor stimulation and protein kinase C activation". J. Cell Biol. 119 (4): 797–810. PMID 1331119.CS1 maint: Multiple names: authors list (link)
• Adams LD, Tomasselli AG, Robbins P; et al. (1992). "HIV-1 protease cleaves actin during acute infection of human T-lymphocytes". AIDS Res. Hum. Retroviruses. 8 (2): 291–5. PMID 1540415.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. PMID 1602151.
• Tomasselli AG, Hui JO, Adams L; et al. (1991). "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus". J. Biol. Chem. 266 (22): 14548–53. PMID 1907279.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shoeman RL, Kesselmier C, Mothes E; et al. (1991). "Non-viral cellular substrates for human immunodeficiency virus type 1 protease". FEBS Lett. 278 (2): 199–203. PMID 1991513.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Erba HP, Eddy R, Shows T; et al. (1988). "Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes". Mol. Cell. Biol. 8 (4): 1775–89. PMID 2837653.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vandekerckhove J, Schering B, Bärmann M, Aktories K (1988). "Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177". J. Biol. Chem. 263 (2): 696–700. PMID 3335520.CS1 maint: Multiple names: authors list (link)
• Chou CC, Davis RC, Fuller ML; et al. (1987). "Gamma-actin: unusual mRNA 3'-untranslated sequence conservation and amino acid substitutions that may be cancer related". Proc. Natl. Acad. Sci. U.S.A. 84 (9): 2575–9. PMID 3472224.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hesterberg LK, Weber K (1986). "Isolation of a domain of villin retaining calcium-dependent interaction with G-actin, but devoid of F-actin fragmenting activity". Eur. J. Biochem. 154 (1): 135–40. PMID 3510866.
• Erba HP, Gunning P, Kedes L (1986). "Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes". Nucleic Acids Res. 14 (13): 5275–94. PMID 3737401.CS1 maint: Multiple names: authors list (link)
• Fuchs E, Kim KH, Hanukoglu I, Tanese N (1984). "The evolution and complexity of the genes encoding the cytoskeletal proteins of human epidermal cells". Curr. Probl. Dermatol. 11: 27–44. PMID 6686106.CS1 maint: Multiple names: authors list (link)
• Gunning P, Ponte P, Okayama H; et al. (1983). "Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed". Mol. Cell. Biol. 3 (5): 787–95. PMID 6865942.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bretscher A, Weber K (1980). "Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner". Cell. 20 (3): 839–47. PMID 6893424.
• Pedrotti B, Colombo R, Islam K (1995). "Microtubule associated protein MAP1A is an actin-binding and crosslinking protein". Cell Motil. Cytoskeleton. 29 (2): 110–6. doi:10.1002/cm.970290203. PMID 7820861.CS1 maint: Multiple names: authors list (link)
• Pope B, Maciver S, Weeds A (1995). "Localization of the calcium-sensitive actin monomer binding site in gelsolin to segment 4 and identification of calcium binding sites". Biochemistry. 34 (5): 1583–8. PMID 7849017.CS1 maint: Multiple names: authors list (link)
• Jesaitis AJ, Erickson RW, Klotz KN; et al. (1993). "Functional molecular complexes of human N-formyl chemoattractant receptors and actin". J. Immunol. 151 (10): 5653–65. PMID 8228254.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hawkins M, Pope B, Maciver SK, Weeds AG (1993). "Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments". Biochemistry. 32 (38): 9985–93. PMID 8399167.CS1 maint: Multiple names: authors list (link)
• Yu FX, Lin SC, Morrison-Bogorad M; et al. (1993). "Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins". J. Biol. Chem. 268 (1): 502–9. PMID 8416954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jalaguier S, Mornet D, Mesnier D; et al. (1996). "Human mineralocorticoid receptor interacts with actin under mineralocorticoid ligand modulation". FEBS Lett. 384 (2): 112–6. PMID 8612804.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)