ACTA2

Actin, alpha 2, smooth muscle, aorta
File:PBB Protein ACTA2 image.jpg PDB rendering based on 1atn.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1atn​, 1c0f​, 1c0g​, 1d4x​, 1dej​, 1eqy​, 1esv​, 1h1v​, 1hlu​, 1ijj​, 1j6z​, 1kxp​, 1lcu​, 1lot​, 1m8q​, 1ma9​, 1mdu​, 1mvw​, 1nlv​, 1nm1​, 1nmd​, 1nwk​, 1o18​, 1o19​, 1o1a​, 1o1b​, 1o1c​, 1o1d​, 1o1e​, 1o1f​, 1o1g​, 1p8z​, 1qz5​, 1qz6​, 1rdw​, 1rfq​, 1rgi​, 1s22​, 1sqk​, 1t44​, 1wua​, 1y64​, 1yxq​, 2a3z​, 2a40​, 2a41​, 2a42​, 2a5x​, 2asm​, 2aso​, 2asp​, 2btf​, 2d1k​, 2ff3​, 2ff6​, 2fxu​, 2gwj​, 2gwk​, 2hf3​, 2hf4​, 2hmp​, 2oan​, 2q1n​, 2q31​, 2q36​
Identifiers
Symbols	ACTA2 ; ACTSA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 48026
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Actin, alpha 2, smooth muscle, aorta, also known as ACTA2, is a human gene.

Actin alpha 2, the human aortic smooth muscle actin gene, is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.

Further reading

• Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biol. (Praha). 42 (5): 227–30. PMID 8997639.
• Adams LD, Tomasselli AG, Robbins P; et al. (1992). "HIV-1 protease cleaves actin during acute infection of human T-lymphocytes". AIDS Res. Hum. Retroviruses. 8 (2): 291–5. PMID 1540415.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harris DE, Warshaw DM, Periasamy M (1992). "Nucleotide sequences of the rabbit alpha-smooth-muscle and beta-non-muscle actin mRNAs". Gene. 112 (2): 265–6. PMID 1555776.CS1 maint: Multiple names: authors list (link)
• Tomasselli AG, Hui JO, Adams L; et al. (1991). "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus". J. Biol. Chem. 266 (22): 14548–53. PMID 1907279.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jahoda CA, Reynolds AJ, Chaponnier C; et al. (1991). "Smooth muscle alpha-actin is a marker for hair follicle dermis in vivo and in vitro". J. Cell. Sci. 99 ( Pt 3): 627–36. PMID 1939373.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueyama H, Ohsugi R (1990). "TaqI polymorphism in the 3' flanking region of the human aortic smooth muscle actin gene". Nucleic Acids Res. 18 (5): 1318. PMID 1969628.
• Shoeman RL, Kesselmier C, Mothes E; et al. (1991). "Non-viral cellular substrates for human immunodeficiency virus type 1 protease". FEBS Lett. 278 (2): 199–203. PMID 1991513.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakano Y, Nishihara T, Sasayama S; et al. (1991). "Transcriptional regulatory elements in the 5' upstream and first intron regions of the human smooth muscle (aortic type) alpha-actin-encoding gene". Gene. 99 (2): 285–9. PMID 2022339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reddy S, Ozgur K, Lu M; et al. (1990). "Structure of the human smooth muscle alpha-actin gene. Analysis of a cDNA and 5' upstream region". J. Biol. Chem. 265 (3): 1683–7. PMID 2295650.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueyama H, Bruns G, Kanda N (1990). "Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome 10". Jinrui Idengaku Zasshi. 35 (2): 145–50. PMID 2398629.CS1 maint: Multiple names: authors list (link)
• Kamada S, Nakano Y, Kakunaga T (1990). "Structure of 3'-downstream segment of the human smooth muscle (aortic-type) alpha-actin-encoding gene and isolation of the specific DNA probe". Gene. 84 (2): 455–62. PMID 2612915.CS1 maint: Multiple names: authors list (link)
• Kamada S, Kakunaga T (1989). "The nucleotide sequence of a human smooth muscle alpha-actin (aortic type) cDNA". Nucleic Acids Res. 17 (4): 1767. PMID 2701935.
• Kedes L, Ng SY, Lin CS; et al. (1986). "The human beta-actin multigene family". Trans. Assoc. Am. Physicians. 98: 42–6. PMID 3842206.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueyama H, Hamada H, Battula N, Kakunaga T (1984). "Structure of a human smooth muscle actin gene (aortic type) with a unique intron site". Mol. Cell. Biol. 4 (6): 1073–8. PMID 6330528.CS1 maint: Multiple names: authors list (link)
• Strauch AR, Rubenstein PA (1984). "A vascular smooth muscle alpha-isoactin biosynthetic intermediate in BC3H1 cells. Identification of acetylcysteine at the NH2 terminus". J. Biol. Chem. 259 (11): 7224–9. PMID 6725286.
• Ueyama H, Inazawa J, Ariyama T; et al. (1995). "Reexamination of chromosomal loci of human muscle actin genes by fluorescence in situ hybridization". Jpn. J. Hum. Genet. 40 (1): 145–8. PMID 7780165.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arora PD, McCulloch CA (1994). "Dependence of collagen remodelling on alpha-smooth muscle actin expression by fibroblasts". J. Cell. Physiol. 159 (1): 161–75. doi:10.1002/jcp.1041590120. PMID 8138584.
• Iwata Y, Pan Y, Yoshida T; et al. (1998). "Alpha1-syntrophin has distinct binding sites for actin and calmodulin". FEBS Lett. 423 (2): 173–7. PMID 9512352.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Comer KA, Dennis PA, Armstrong L; et al. (1998). "Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein". Oncogene. 16 (10): 1299–308. doi:10.1038/sj.onc.1201645. PMID 9546431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)