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{{Infobox_gene}}
{{PBB_Controls
'''Adaptor-associated protein kinase 1''' also known as '''AP2-associated protein kinase 1''' is an [[enzyme]] that in humans is encoded by the ''AAK1'' [[gene]].<ref name="pmid11877461">{{cite journal | vauthors = Conner SD, Schmid SL | title = Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis | journal = The Journal of Cell Biology | volume = 156 | issue = 5 | pages = 921–9 | date = Mar 2002 | pmid = 11877461 | pmc = 2173317 | doi = 10.1083/jcb.200108123 }}</ref><ref name="pmid12471243">{{cite journal | vauthors = Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S | title = The protein kinase complement of the human genome | journal = Science | volume = 298 | issue = 5600 | pages = 1912–34 | date = Dec 2002 | pmid = 12471243 | pmc = | doi = 10.1126/science.1075762 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AAK1 AP2 associated kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22848| accessdate = }}</ref> Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = AP2 associated kinase 1
| HGNCid = 19679
| Symbol = AAK1
| AltSymbols =; KIAA1048; MGC138170
| OMIM = 
| ECnumber = 
| Homologene = 75032
| MGIid = 1098687
| GeneAtlas_image1 = PBB_GE_AAK1_205435_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_AAK1_211186_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22848
    | Hs_Ensembl = ENSG00000115977
    | Hs_RefseqProtein = NP_055726
    | Hs_RefseqmRNA = NM_014911
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 69561706
    | Hs_GenLoc_end = 69723771
    | Hs_Uniprot = Q2M2I8
    | Mm_EntrezGene = 269774
    | Mm_Ensembl = ENSMUSG00000057230
    | Mm_RefseqmRNA = NM_001040106
    | Mm_RefseqProtein = NP_001035195
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 86815474
    | Mm_GenLoc_end = 86957498
    | Mm_Uniprot = Q3UHJ0
  }}
}}
'''AP2 associated kinase 1''', also known as '''AAK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AAK1 AP2 associated kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22848| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Adaptor-related protein complex 2 ([[AP2 adaptors|AP-2 complexes]]) functions during receptor-mediated [[endocytosis]] to trigger [[clathrin]] assembly, interact with membrane-bound receptors, and recruit endocytic accessory factors. This gene encodes a member of the SNF1 subfamily of [[serine/threonine-specific protein kinase|Ser/Thr protein kinase]]s. The protein interacts with and [[phosphorylation|phosphorylates]] a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: AAK1 AP2 associated kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22848| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 3 | pages = 197–205 | date = Jun 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 }}
| citations =
* {{cite journal | vauthors = Ricotta D, Conner SD, Schmid SL, von Figura K, Honing S | title = Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals | journal = The Journal of Cell Biology | volume = 156 | issue = 5 | pages = 791–5 | date = Mar 2002 | pmid = 11877457 | pmc = 2173304 | doi = 10.1083/jcb.200111068 }}
*{{cite journal  | author=Manning G, Whyte DB, Martinez R, ''et al.'' |title=The protein kinase complement of the human genome. |journal=Science |volume=298 |issue= 5600 |pages= 1912-34 |year= 2003 |pmid= 12471243 |doi= 10.1126/science.1075762 }}
* {{cite journal | vauthors = Conner SD, Schmid SL | title = Differential requirements for AP-2 in clathrin-mediated endocytosis | journal = The Journal of Cell Biology | volume = 162 | issue = 5 | pages = 773–9 | date = Sep 2003 | pmid = 12952931 | pmc = 2172816 | doi = 10.1083/jcb.200304069 }}
*{{cite journal | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi=  }}
* {{cite journal | vauthors = Conner SD, Schröter T, Schmid SL | title = AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin | journal = Traffic | volume = 4 | issue = 12 | pages = 885–90 | date = Dec 2003 | pmid = 14617351 | doi = 10.1046/j.1398-9219.2003.0142.x }}
*{{cite journal | author=Ricotta D, Conner SD, Schmid SL, ''et al.'' |title=Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals. |journal=J. Cell Biol. |volume=156 |issue= 5 |pages= 791-5 |year= 2002 |pmid= 11877457 |doi= 10.1083/jcb.200111068 }}
* {{cite journal | vauthors = Mishra SK, Hawryluk MJ, Brett TJ, Keyel PA, Dupin AL, Jha A, Heuser JE, Fremont DH, Traub LM | title = Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage | journal = The Journal of Biological Chemistry | volume = 279 | issue = 44 | pages = 46191–203 | date = Oct 2004 | pmid = 15292237 | doi = 10.1074/jbc.M408095200 }}
*{{cite journal  | author=Conner SD, Schmid SL |title=Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. |journal=J. Cell Biol. |volume=156 |issue= 5 |pages= 921-9 |year= 2002 |pmid= 11877461 |doi= 10.1083/jcb.200108123 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kim JE, Tannenbaum SR, White FM | title = Global phosphoproteome of HT-29 human colon adenocarcinoma cells | journal = Journal of Proteome Research | volume = 4 | issue = 4 | pages = 1339–46 | year = 2005 | pmid = 16083285 | doi = 10.1021/pr050048h }}
*{{cite journal  | author=Conner SD, Schmid SL |title=Differential requirements for AP-2 in clathrin-mediated endocytosis. |journal=J. Cell Biol. |volume=162 |issue= 5 |pages= 773-9 |year= 2003 |pmid= 12952931 |doi= 10.1083/jcb.200304069 }}
* {{cite journal | vauthors = Collawn JF | title = Unlocking the mysteries of Na+-K+-ATPase endocytosis: phosphorylation is the key | journal = American Journal of Respiratory Cell and Molecular Biology | volume = 35 | issue = 1 | pages = 1–2 | date = Jul 2006 | pmid = 16782842 | pmc = 2658690 | doi = 10.1165/rcmb.f317 }}
*{{cite journal | author=Conner SD, Schröter T, Schmid SL |title=AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin. |journal=Traffic |volume=4 |issue= 12 |pages= 885-90 |year= 2004 |pmid= 14617351 |doi= }}
* {{cite journal | vauthors = Schmid EM, Ford MG, Burtey A, Praefcke GJ, Peak-Chew SY, Mills IG, Benmerah A, McMahon HT | title = Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly | journal = PLoS Biology | volume = 4 | issue = 9 | pages = e262 | date = Sep 2006 | pmid = 16903783 | pmc = 1540706 | doi = 10.1371/journal.pbio.0040262 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = Oct 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=Mishra SK, Hawryluk MJ, Brett TJ, ''et al.'' |title=Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage. |journal=J. Biol. Chem. |volume=279 |issue= 44 |pages= 46191-203 |year= 2004 |pmid= 15292237 |doi= 10.1074/jbc.M408095200 }}
* {{cite journal | vauthors = Takahashi T, Furuchi T, Naganuma A | title = Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells | journal = Cancer Research | volume = 66 | issue = 24 | pages = 11932–7 | date = Dec 2006 | pmid = 17178891 | doi = 10.1158/0008-5472.CAN-06-3220 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Henderson DM, Conner SD | title = A novel AAK1 splice variant functions at multiple steps of the endocytic pathway | journal = Molecular Biology of the Cell | volume = 18 | issue = 7 | pages = 2698–706 | date = Jul 2007 | pmid = 17494869 | pmc = 1924820 | doi = 10.1091/mbc.E06-09-0831 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339-46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Collawn JF |title=Unlocking the mysteries of Na+-K+-ATPase endocytosis: phosphorylation is the key. |journal=Am. J. Respir. Cell Mol. Biol. |volume=35 |issue= 1 |pages= 1-2 |year= 2006 |pmid= 16782842 |doi= 10.1165/rcmb.f317 }}
*{{cite journal | author=Schmid EM, Ford MG, Burtey A, ''et al.'' |title=Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. |journal=PLoS Biol. |volume=4 |issue= 9 |pages= e262 |year= 2007 |pmid= 16903783 |doi= 10.1371/journal.pbio.0040262 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Takahashi T, Furuchi T, Naganuma A |title=Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells. |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11932-7 |year= 2007 |pmid= 17178891 |doi= 10.1158/0008-5472.CAN-06-3220 }}
*{{cite journal | author=Henderson DM, Conner SD |title=A novel AAK1 splice variant functions at multiple steps of the endocytic pathway. |journal=Mol. Biol. Cell |volume=18 |issue= 7 |pages= 2698-706 |year= 2007 |pmid= 17494869 |doi= 10.1091/mbc.E06-09-0831 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|AAK1}} 
* {{UCSC gene details|AAK1}}
 
{{gene-2-stub}}
{{DEFAULTSORT:Aak1}}

Latest revision as of 23:29, 9 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene.[1][2][3] Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]

Function

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit endocytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.[3]

References

  1. ↑ Conner SD, Schmid SL (Mar 2002). "Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis". The Journal of Cell Biology. 156 (5): 921–9. doi:10.1083/jcb.200108123. PMC 2173317. PMID 11877461.
  2. ↑ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (Dec 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243.
  3. ↑ 3.0 3.1 3.2 "Entrez Gene: AAK1 AP2 associated kinase 1".

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=AAK1&oldid=1531660"