3-hydroxyisobutyryl-CoA hydrolase

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In enzymology, a 3-hydroxyisobutyryl-CoA hydrolase (EC is an enzyme that catalyzes the chemical reaction

3-hydroxy-2-methylpropanoyl-CoA + H2O CoA + 3-hydroxy-2-methylpropanoate

Thus, the two substrates of this enzyme are 3-hydroxy-2-methylpropanoyl-CoA and H2O, whereas its two products are CoA and 3-hydroxy-2-methylpropanoate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, beta-alanine metabolism, and propanoate metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Rendina G and Coon MJ (1957). "Enzymatic hydrolysis of the coenzyme A thiol esters of beta-hydroxypropionic and beta-hydroxyisobutyric acids". J. Biol. Chem. 225: 523&ndash, 534.

External links

The CAS registry number for this enzyme class is 9025-88-1.

Gene Ontology (GO) codes