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Pathogen-Based Therapy Adapted from Circulation 2008;118(15):e523-661.

Viridans Streptococci or Streptococcus bovis

▸ Click on the following categories to expand treatment regimens.

Native Valve Endocarditis   ▸  Penicillin-Susceptible, Adult   ▸  Penicillin-Susceptible, Pediatric   ▸  Penicillin-Resistant, Adult   ▸  Penicillin-Resistant, Pediatric Prosthetic Valve Endocarditis   ▸  Penicillin-Susceptible, Adult   ▸  Penicillin-Susceptible, Pediatric   ▸  Penicillin-Resistant, Adult   ▸  Penicillin-Resistant, Pediatric

Viridans Streptococci or S. bovis NVE, PCN-Susceptible, Adult Preferred Regimen ▸ Penicillin G sodium 12—18 MU/day IV continuously/q4—6h x 4 weeks OR ▸ Ceftriaxone 2 g IV/IM q24h x 4 weeks Alternative Regimen 1 ▸ Penicillin G sodium 12—18 MU/day IV continuously/q4—6h x 2 weeks OR ▸ Ceftriaxone 2 g IV/IM q24h x 2 weeks PLUS ▸ Gentamicin 3 mg/kg IV q24h x 2 weeks Alternative Regimen 2 ▸ Vancomycin 15 mg/kg IV q12h x 4 weeks