Scrub typhus history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

History and Symptoms

Symptoms include fever, headache, muscle pain, cough, and gastrointestinal symptoms. More virulent strains of O. tsutsugamushi can cause hemorrhaging and intravascular coagulation. Maculopapular rash, eschar, splenomegaly and lymphadenopathies are typical signs. Leukopenia and abnormal liver function tests are commonly seen in the early phase of the illness. Pneumonitis, encephalitis, and myocarditis occur in the late phase of illness.

Acute scrub typhus appears to improve viral loads in patients with HIV.[1] This interaction is refused by an in vitro study.[2]

References

  1. Watt G; Kantipong P; de Souza M; et al. (2000). "HIV-1 suppression during acute scrub-typhus infection". Lancet. 356 (9228): 475–479. doi:10.1016/S0140-6736(00)02557-5. PMID 10981892. Unknown parameter |author-separator= ignored (help)
  2. Moriuchi M, Tamura A, Moriuchi H. (2003). "In vitro reactivation of human immunodeficiency virus-1 upon stimulation with scrub typhus rickettsial infection". Am J Trop Med Hyg. 68 (5): 557–561. PMID 12812345.

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