UHRF1

Ubiquitin-like, containing PHD and RING finger domains, 1
File:PBB Protein UHRF1 image.jpg PDB rendering based on 2faz.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2faz​
Identifiers
Symbols	UHRF1 ; FLJ21925; ICBP90; MGC138707; Np95; RNF106
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7866
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE UHRF1 gnf1h00130 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a human gene.

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Ku DH, Chang CD, Koniecki J; et al. (1991). "A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor". Cell Growth Differ. 2 (4): 179–86. PMID 1868030.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hopfner R, Mousli M, Jeltsch JM; et al. (2000). "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression". Cancer Res. 60 (1): 121–8. PMID 10646863.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hopfner R, Mousli M, Garnier JM; et al. (2001). "Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression". Gene. 266 (1–2): 15–23. PMID 11290415.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mousli M, Hopfner R, Abbady AQ; et al. (2003). "ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells". Br. J. Cancer. 89 (1): 120–7. doi:10.1038/sj.bjc.6601068. PMID 12838312.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Citterio E, Papait R, Nicassio F; et al. (2004). "Np95 is a histone-binding protein endowed with ubiquitin ligase activity". Mol. Cell. Biol. 24 (6): 2526–35. PMID 14993289.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arima Y, Hirota T, Bronner C; et al. (2004). "Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition". Genes Cells. 9 (2): 131–42. PMID 15009091.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abbady AQ, Bronner C, Trotzier MA; et al. (2004). "ICBP90 expression is downregulated in apoptosis-induced Jurkat cells". Ann. N. Y. Acad. Sci. 1010: 300–3. PMID 15033738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Trotzier MA, Bronner C, Bathami K; et al. (2004). "Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression". Biochem. Biophys. Res. Commun. 319 (2): 590–5. doi:10.1016/j.bbrc.2004.05.028. PMID 15178447.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain". Oncogene. 23 (46): 7601–10. doi:10.1038/sj.onc.1208053. PMID 15361834.CS1 maint: Multiple names: authors list (link)
• Abbady AQ, Bronner C, Bathami K; et al. (2005). "TCR pathway involves ICBP90 gene down-regulation via E2F binding sites". Biochem. Pharmacol. 70 (4): 570–9. doi:10.1016/j.bcp.2005.05.012. PMID 15964557.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jeanblanc M, Mousli M, Hopfner R; et al. (2005). "The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle". Oncogene. 24 (49): 7337–45. doi:10.1038/sj.onc.1208878. PMID 16007129.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jenkins Y, Markovtsov V, Lang W; et al. (2006). "Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth". Mol. Biol. Cell. 16 (12): 5621–9. doi:10.1091/mbc.E05-03-0194. PMID 16195352.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Muto M, Fujimori A, Nenoi M; et al. (2006). "Isolation and Characterization of a Novel Human Radiosusceptibility Gene, NP95". Radiat. Res. 166 (5): 723–33. doi:10.1667/RR0459.1. PMID 17067204.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)