SPOCK1
| Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SPOCK1 ; FLJ37170; SPOCK; TESTICAN; TIC1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 80193 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1, also known as SPOCK1, is a human gene.[1]
This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition.[1]
References
Further reading
- Périn JP, Alliel PM, Jollès P, Bonnet F (1994). "Proteoglycans in male reproductive tract". EXS. 70: 191–7. PMID 7507743.
- Charbonnier F, Périn JP, Roussel G; et al. (1997). "[Cloning of testican/SPOCK in man and mouse. Neuromuscular expression perspectives in pathology]". C. R. Seances Soc. Biol. Fil. 191 (1): 127–33. PMID 9181134.
- Alliel PM, Perin JP, Jollès P, Bonnet FJ (1993). "Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour". Eur. J. Biochem. 214 (1): 347–50. PMID 8389704.
- Bonnet F, Périn JP, Charbonnier F; et al. (1996). "Structure and cellular distribution of mouse brain testican. Association with the postsynaptic area of hippocampus pyramidal cells". J. Biol. Chem. 271 (8): 4373–80. PMID 8626787.
- Marr HS, Basalamah MA, Edgell CJ (1998). "Endothelial cell expression of testican mRNA". Endothelium. 5 (3): 209–19. PMID 9272383.
- Kohfeldt E, Maurer P, Vannahme C, Timpl R (1997). "Properties of the extracellular calcium binding module of the proteoglycan testican". FEBS Lett. 414 (3): 557–61. PMID 9323035.
- Charbonnier F, Périn JP, Mattei MG; et al. (1998). "Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31". Genomics. 48 (3): 377–80. doi:10.1006/geno.1997.5199. PMID 9545645.
- Marr HS, Basalamah MA, Bouldin TW; et al. (2001). "Distribution of testican expression in human brain". Cell Tissue Res. 302 (2): 139–44. PMID 11131125.
- BaSalamah MA, Marr HS, Duncan AW, Edgell CJ (2001). "Testican in human blood". Biochem. Biophys. Res. Commun. 283 (5): 1083–90. doi:10.1006/bbrc.2001.4900. PMID 11355883.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Nakada M, Miyamori H, Yamashita J, Sato H (2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins". Cancer Res. 63 (12): 3364–9. PMID 12810672.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Schmutz J, Martin J, Terry A; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
- Prenzel KL, Warnecke-Eberz U, Xi H; et al. (2006). "Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater". Oncol. Rep. 15 (5): 1397–401. PMID 16596217.
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