RBMX

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RNA binding motif protein, X-linked
Identifiers
Symbols RBMX ; RBMXP1; HNRPG; RBMXRT; RNMX
External IDs Template:OMIM5 Template:MGI HomoloGene20494
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

RNA binding motif protein, X-linked, also known as RBMX, is a human gene.[1]

This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified but their biological nature has not been determined.[1]

References

  1. 1.0 1.1 "Entrez Gene: RBMX RNA binding motif protein, X-linked".

Further reading

  • Le Coniat M, Soulard M, Della Valle V; et al. (1992). "Localization of the human gene encoding heterogeneous nuclear RNA ribonucleoprotein G (hnRNP-G) to chromosome 6p12". Hum. Genet. 88 (5): 593–5. PMID 1551662.
  • Soulard M, Della Valle V, Siomi MC; et al. (1993). "hnRNP G: sequence and characterization of a glycosylated RNA-binding protein". Nucleic Acids Res. 21 (18): 4210–7. PMID 7692398.
  • Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.
  • Venables JP, Vernet C, Chew SL; et al. (1999). "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis". Hum. Mol. Genet. 8 (6): 959–69. PMID 10332027.
  • Delbridge ML, Lingenfelter PA, Disteche CM, Graves JA (1999). "The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome". Nat. Genet. 22 (3): 223–4. doi:10.1038/10279. PMID 10391206.
  • Mazeyrat S, Saut N, Mattei MG, Mitchell MJ (1999). "RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene". Nat. Genet. 22 (3): 224–6. doi:10.1038/10282. PMID 10391207.
  • Venables JP, Elliott DJ, Makarova OV; et al. (2000). "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing". Hum. Mol. Genet. 9 (5): 685–94. PMID 10749975.
  • Ajuh P, Kuster B, Panov K; et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMID 11101529.
  • Lingenfelter PA, Delbridge ML, Thomas S; et al. (2001). "Expression and conservation of processed copies of the RBMX gene". Mamm. Genome. 12 (7): 538–45. PMID 11420617.
  • Jurica MS, Licklider LJ, Gygi SR; et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. PMID 11991638.
  • Hofmann Y, Wirth B (2003). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Hum. Mol. Genet. 11 (17): 2037–49. PMID 12165565.
  • Angenstein F, Evans AM, Settlage RE; et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". J. Neurosci. 22 (20): 8827–37. PMID 12388589.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Li J, Hawkins IC, Harvey CD; et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. PMID 14559993.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brill LM, Salomon AR, Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
  • Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nat. Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174.

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