PTP4A3

Protein tyrosine phosphatase type IVA, member 3
File:PBB Protein PTP4A3 image.jpg PDB rendering based on 1r6h.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1r6h​, 1v3a​
Identifiers
Symbols	PTP4A3 ; PRL3; PRL-3; PRL-R
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22500
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PTP4A3 209695 at tn.png
File:PBB GE PTP4A3 206574 s at tn.png
File:PBB GE PTP4A3 214223 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase type IVA, member 3, also known as PTP4A3, is a human gene.

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.

Further reading

• Zeng Q, Hong W, Tan YH (1998). "Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1". Biochem. Biophys. Res. Commun. 244 (2): 421–7. doi:10.1006/bbrc.1998.8291. PMID 9514946.CS1 maint: Multiple names: authors list (link)
• Dayton MA, Knobloch TJ (1998). "Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38". Receptors & signal transduction. 7 (4): 241–56. PMID 9633825.
• Zeng Q, Si X, Horstmann H; et al. (2000). "Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome". J. Biol. Chem. 275 (28): 21444–52. doi:10.1074/jbc.M000453200. PMID 10747914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matter WF, Estridge T, Zhang C; et al. (2001). "Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling". Biochem. Biophys. Res. Commun. 283 (5): 1061–8. doi:10.1006/bbrc.2001.4881. PMID 11355880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saha S, Bardelli A, Buckhaults P; et al. (2001). "A phosphatase associated with metastasis of colorectal cancer". Science. 294 (5545): 1343–6. doi:10.1126/science.1065817. PMID 11598267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang J, Kirby CE, Herbst R (2003). "The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis". J. Biol. Chem. 277 (48): 46659–68. doi:10.1074/jbc.M206407200. PMID 12235145.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pathak MK, Dhawan D, Lindner DJ; et al. (2003). "Pentamidine is an inhibitor of PRL phosphatases with anticancer activity". Mol. Cancer Ther. 1 (14): 1255–64. PMID 12516958.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zeng Q, Dong JM, Guo K; et al. (2003). "PRL-3 and PRL-1 promote cell migration, invasion, and metastasis". Cancer Res. 63 (11): 2716–22. PMID 12782572.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bardelli A, Saha S, Sager JA; et al. (2004). "PRL-3 expression in metastatic cancers". Clin. Cancer Res. 9 (15): 5607–15. PMID 14654542.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kozlov G, Cheng J, Ziomek E; et al. (2004). "Structural insights into molecular function of the metastasis-associated phosphatase PRL-3". J. Biol. Chem. 279 (12): 11882–9. doi:10.1074/jbc.M312905200. PMID 14704153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim KA, Song JS, Jee J; et al. (2004). "Structure of human PRL-3, the phosphatase associated with cancer metastasis". FEBS Lett. 565 (1–3): 181–7. doi:10.1016/j.febslet.2004.03.062. PMID 15135076.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu X, Zeng H, Zhang X; et al. (2004). "Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells". Am. J. Pathol. 164 (6): 2039–54. PMID 15161639.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato H, Semba S, Miskad UA; et al. (2005). "High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases". Clin. Cancer Res. 10 (21): 7318–28. doi:10.1158/1078-0432.CCR-04-0485. PMID 15534108.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li J, Guo K, Koh VW; et al. (2005). "Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases". Clin. Cancer Res. 11 (6): 2195–204. doi:10.1158/1078-0432.CCR-04-1984. PMID 15788667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Polato F, Codegoni A, Fruscio R; et al. (2006). "PRL-3 phosphatase is implicated in ovarian cancer growth". Clin. Cancer Res. 11 (19 Pt 1): 6835–9. doi:10.1158/1078-0432.CCR-04-2357. PMID 16203771.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Peng L, Jin G, Wang L; et al. (2006). "Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3". Biochem. Biophys. Res. Commun. 342 (1): 179–83. doi:10.1016/j.bbrc.2006.01.102. PMID 16472776.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rouleau C, Roy A, St Martin T; et al. (2006). "Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function". Mol. Cancer Ther. 5 (2): 219–29. doi:10.1158/1535-7163.MCT-05-0289. PMID 16505094.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Radke I, Götte M, Kersting C; et al. (2006). "Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer". Br. J. Cancer. 95 (3): 347–54. doi:10.1038/sj.bjc.6603261. PMID 16832410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)