OAS2

2'-5'-oligoadenylate synthetase 2, 69/71kDa
Identifiers
Symbols	OAS2 ; MGC78578
External IDs	Template:OMIM5 Template:MGI HomoloGene: 49478
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE OAS2 204972 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

2'-5'-oligoadenylate synthetase 2, 69/71kDa, also known as OAS2, is a human gene.

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.

Further reading

• Justesen J, Hartmann R, Kjeldgaard NO (2000). "Gene structure and function of the 2'-5'-oligoadenylate synthetase family". Cell. Mol. Life Sci. 57 (11): 1593–612. PMID 11092454.CS1 maint: Multiple names: authors list (link)
• Marié I, Hovanessian AG (1992). "The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains". J. Biol. Chem. 267 (14): 9933–9. PMID 1577824.
• Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
• Marié I, Svab J, Robert N; et al. (1990). "Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon". J. Biol. Chem. 265 (30): 18601–7. PMID 2211721.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hovanessian AG, Laurent AG, Chebath J; et al. (1987). "Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies". EMBO J. 6 (5): 1273–80. PMID 2440675.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marié I, Galabru J, Svab J, Hovanessian AG (1989). "Preparation and characterization of polyclonal antibodies specific for the 69 and 100 k-dalton forms of human 2-5A synthetase". Biochem. Biophys. Res. Commun. 160 (2): 580–7. PMID 2470369.CS1 maint: Multiple names: authors list (link)
• Hovanessian AG, Svab J, Marié I; et al. (1988). "Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells". J. Biol. Chem. 263 (10): 4945–9. PMID 3350819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Solinas A, Cossu P, Poddighe P; et al. (1994). "Changes of serum 2',5'-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis C.". Liver. 13 (5): 253–8. PMID 8259037.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Besse S, Rebouillat D, Marie I; et al. (1998). "Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells". Exp. Cell Res. 239 (2): 379–92. PMID 9521856.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hovnanian A, Rebouillat D, Mattei MG; et al. (1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics. 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sarkar SN, Ghosh A, Wang HW; et al. (1999). "The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases". J. Biol. Chem. 274 (36): 25535–42. PMID 10464285.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SE, Muzny DM, Buhay CJ; et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)