NEIL1

Nei endonuclease VIII-like 1 (E. coli)
File:PBB Protein NEIL1 image.jpg PDB rendering based on 1tdh.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1tdh​
Identifiers
Symbols	NEIL1 ; FLJ22402; NEI1; hFPG1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11616
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NEIL1 219396 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nei endonuclease VIII-like 1 (E. coli), also known as NEIL1, is a human gene.

NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002).[supplied by OMIM]

Further reading

• Hazra TK, Izumi T, Boldogh I; et al. (2002). "Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3523–8. doi:10.1073/pnas.062053799. PMID 11904416.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takao M, Kanno S, Kobayashi K; et al. (2003). "A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue". J. Biol. Chem. 277 (44): 42205–13. doi:10.1074/jbc.M206884200. PMID 12200441.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morland I, Rolseth V, Luna L; et al. (2002). "Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA". Nucleic Acids Res. 30 (22): 4926–36. PMID 12433996.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bandaru V, Sunkara S, Wallace SS, Bond JP (2003). "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII". DNA Repair (Amst.). 1 (7): 517–29. PMID 12509226.CS1 maint: Multiple names: authors list (link)
• Dou H, Mitra S, Hazra TK (2004). "Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2". J. Biol. Chem. 278 (50): 49679–84. doi:10.1074/jbc.M308658200. PMID 14522990.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katafuchi A, Nakano T, Masaoka A; et al. (2004). "Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions". J. Biol. Chem. 279 (14): 14464–71. doi:10.1074/jbc.M400393200. PMID 14734554.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bandaru V, Cooper W, Wallace SS, Doublié S (2005). "Overproduction, crystallization and preliminary crystallographic analysis of a novel human DNA-repair enzyme that recognizes oxidative DNA damage". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 6): 1142–4. doi:10.1107/S0907444904007929. PMID 15159582.CS1 maint: Multiple names: authors list (link)
• Doublié S, Bandaru V, Bond JP, Wallace SS (2004). "The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity". Proc. Natl. Acad. Sci. U.S.A. 101 (28): 10284–9. doi:10.1073/pnas.0402051101. PMID 15232006.CS1 maint: Multiple names: authors list (link)
• Wiederhold L, Leppard JB, Kedar P; et al. (2004). "AP endonuclease-independent DNA base excision repair in human cells". Mol. Cell. 15 (2): 209–20. doi:10.1016/j.molcel.2004.06.003. PMID 15260972.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shinmura K, Tao H, Goto M; et al. (2005). "Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer". Carcinogenesis. 25 (12): 2311–7. doi:10.1093/carcin/bgh267. PMID 15319300.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mokkapati SK, Wiederhold L, Hazra TK, Mitra S (2004). "Stimulation of DNA glycosylase activity of OGG1 by NEIL1: functional collaboration between two human DNA glycosylases". Biochemistry. 43 (36): 11596–604. doi:10.1021/bi049097i. PMID 15350146.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang QM, Yonekura S, Takao M; et al. (2005). "DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells". DNA Repair (Amst.). 4 (1): 71–9. doi:10.1016/j.dnarep.2004.08.002. PMID 15533839.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Das A, Hazra TK, Boldogh I; et al. (2005). "Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species". J. Biol. Chem. 280 (42): 35272–80. doi:10.1074/jbc.M505526200. PMID 16118226.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ocampo-Hafalla MT, Altamirano A, Basu AK; et al. (2006). "Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerization". DNA Repair (Amst.). 5 (4): 444–54. doi:10.1016/j.dnarep.2005.12.004. PMID 16446124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Broderick P, Bagratuni T, Vijayakrishnan J; et al. (2006). "Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition". BMC Cancer. 6: 243. doi:10.1186/1471-2407-6-243. PMID 17029639.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katafuchi A, Matsubara M, Terato H; et al. (2007). "Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions". Nucleic Acids Symp Ser (Oxf) (48): 175–6. doi:10.1093/nass/48.1.175. PMID 17150535.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)