DKK1

Dickkopf homolog 1 (Xenopus laevis)
Identifiers
Symbols	DKK1 ; DKK-1; SK
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7689
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Dickkopf homolog 1 (Xenopus laevis), also known as DKK1, is a human gene.

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Further reading

• Fedi P, Bafico A, Nieto Soria A; et al. (1999). "Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling". J. Biol. Chem. 274 (27): 19465–72. PMID 10383463.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krupnik VE, Sharp JD, Jiang C; et al. (1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. PMID 10570958.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roessler E, Du Y, Glinka A; et al. (2000). "The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly". Cytogenet. Cell Genet. 89 (3–4): 220–4. PMID 10965128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mao B, Wu W, Li Y; et al. (2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. 411 (6835): 321–5. doi:10.1038/35077108. PMID 11357136.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Semënov MV, Tamai K, Brott BK; et al. (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–61. PMID 11448771.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zorn AM (2001). "Wnt signalling: antagonistic Dickkopfs". Curr. Biol. 11 (15): R592–5. PMID 11516963.
• Shou J, Ali-Osman F, Multani AS; et al. (2002). "Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA". Oncogene. 21 (6): 878–89. doi:10.1038/sj.onc.1205138. PMID 11840333.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mao B, Wu W, Davidson G; et al. (2002). "Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling". Nature. 417 (6889): 664–7. doi:10.1038/nature756. PMID 12050670.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brott BK, Sokol SY (2002). "Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins". Mol. Cell. Biol. 22 (17): 6100–10. PMID 12167704.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory CA, Singh H, Perry AS, Prockop DJ (2003). "The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow". J. Biol. Chem. 278 (30): 28067–78. doi:10.1074/jbc.M300373200. PMID 12740383.CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tian E, Zhan F, Walker R; et al. (2004). "The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma". N. Engl. J. Med. 349 (26): 2483–94. doi:10.1056/NEJMoa030847. PMID 14695408.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamaguchi Y, Itami S, Watabe H; et al. (2004). "Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation". J. Cell Biol. 165 (2): 275–85. doi:10.1083/jcb.200311122. PMID 15117970.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Caricasole A, Copani A, Caraci F; et al. (2004). "Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain". J. Neurosci. 24 (26): 6021–7. doi:10.1523/JNEUROSCI.1381-04.2004. PMID 15229249.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
• Niida A, Hiroko T, Kasai M; et al. (2004). "DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway". Oncogene. 23 (52): 8520–6. doi:10.1038/sj.onc.1207892. PMID 15378020.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee AY, He B, You L; et al. (2004). "Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma". Biochem. Biophys. Res. Commun. 323 (4): 1246–50. doi:10.1016/j.bbrc.2004.09.001. PMID 15451431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)