Cyclin H

Cyclin H
PDB rendering based on 1jkw.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1jkw​, 1kxu​
Identifiers
Symbols	CCNH ; CAK; p34; p37
External IDs	Template:OMIM5 Template:MGI HomoloGene: 946
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cyclin H, also known as CCNH, is a human gene.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.

Further reading

• Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. PMID 9570510.
• Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. PMID 9651670.
• Shiekhattar R, Mermelstein F, Fisher RP; et al. (1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature. 374 (6519): 283–7. doi:10.1038/374283a0. PMID 7533895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Darbon JM, Devault A, Taviaux S; et al. (1994). "Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase". Oncogene. 9 (11): 3127–38. PMID 7936635.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feaver WJ, Svejstrup JQ, Henry NL, Kornberg RD (1995). "Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK". Cell. 79 (6): 1103–9. PMID 8001136.CS1 maint: Multiple names: authors list (link)
• Fisher RP, Morgan DO (1994). "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase". Cell. 78 (4): 713–24. PMID 8069918.
• Mäkelä TP, Tassan JP, Nigg EA; et al. (1994). "A cyclin associated with the CDK-activating kinase MO15". Nature. 371 (6494): 254–7. doi:10.1038/371254a0. PMID 8078587.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Perez JL, Shen X, Finkernagel S; et al. (1994). "Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain". Oncogene. 9 (1): 211–9. PMID 8302582.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tassan JP, Jaquenoud M, Fry AM; et al. (1996). "In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein". EMBO J. 14 (22): 5608–17. PMID 8521818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adamczewski JP, Rossignol M, Tassan JP; et al. (1996). "MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH". EMBO J. 15 (8): 1877–84. PMID 8617234.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blau J, Xiao H, McCracken S; et al. (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. PMID 8628270.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reardon JT, Ge H, Gibbs E; et al. (1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6482–7. PMID 8692841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Drapkin R, Le Roy G, Cho H; et al. (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. PMID 8692842.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim KK, Chamberlin HM, Morgan DO, Kim SH (1996). "Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase". Nat. Struct. Biol. 3 (10): 849–55. PMID 8836101.CS1 maint: Multiple names: authors list (link)
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. PMID 8849451.
• Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. doi:10.1038/384375a0. PMID 8934526.
• García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. PMID 9054383.CS1 maint: Multiple names: authors list (link)
• Poterszman A, Andersen G, Busso D; et al. (1997). "Expression in Escherichia coli: purification and characterization of cyclin H, a subunit of the human general transcription/DNA repair factor TFIIH". Protein Expr. Purif. 9 (2): 153–8. doi:10.1006/prep.1996.0693. PMID 9056480.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marinoni JC, Roy R, Vermeulen W; et al. (1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMID 9118947.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen G, Busso D, Poterszman A; et al. (1997). "The structure of cyclin H: common mode of kinase activation and specific features". EMBO J. 16 (5): 958–67. doi:10.1093/emboj/16.5.958. PMID 9118957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)