B-cell linker
| B-cell linker | |||||||||||
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| Identifiers | |||||||||||
| Symbols | BLNK ; BASH; BLNK-s; Ly57; MGC111051; SLP-65; SLP65 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 32038 | ||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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B-cell linker, also known as BLNK, is a human gene.[1]
Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.[supplied by OMIM][1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Fu C, Chan AC (1997). "Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation". J. Biol. Chem. 272 (43): 27362–8. PMID 9341187.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Fu C, Turck CW, Kurosaki T, Chan AC (1998). "BLNK: a central linker protein in B cell activation". Immunity. 9 (1): 93–103. PMID 9697839.
- Wienands J, Schweikert J, Wollscheid B; et al. (1998). "SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation". J. Exp. Med. 188 (4): 791–5. PMID 9705962.
- Hashimoto S, Iwamatsu A, Ishiai M; et al. (1999). "Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling". Blood. 94 (7): 2357–64. PMID 10498607.
- Su YW, Zhang Y, Schweikert J; et al. (1999). "Interaction of SLP adaptors with the SH2 domain of Tec family kinases". Eur. J. Immunol. 29 (11): 3702–11. PMID 10556826.
- Minegishi Y, Rohrer J, Coustan-Smith E; et al. (1999). "An essential role for BLNK in human B cell development". Science. 286 (5446): 1954–7. PMID 10583958.
- Fusaki N, Tomita S, Wu Y; et al. (2000). "BLNK is associated with the CD72/SHP-1/Grb2 complex in the WEHI231 cell line after membrane IgM cross-linking". Eur. J. Immunol. 30 (5): 1326–30. PMID 10820378.
- Mizuno K, Tagawa Y, Mitomo K; et al. (2000). "Src homology region 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells". J. Immunol. 165 (3): 1344–51. PMID 10903736.
- Guo B, Kato RM, Garcia-Lloret M; et al. (2000). "Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex". Immunity. 13 (2): 243–53. PMID 10981967.
- Watanabe S, Take H, Takeda K; et al. (2001). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochem. Biophys. Res. Commun. 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. PMID 11071869.
- Tan JE, Wong SC, Gan SK; et al. (2001). "The adaptor protein BLNK is required for b cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytes". J. Biol. Chem. 276 (23): 20055–63. doi:10.1074/jbc.M010800200. PMID 11274146.
- Adachi T, Wienands J, Wakabayashi C; et al. (2001). "SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates". J. Biol. Chem. 276 (28): 26648–55. doi:10.1074/jbc.M100997200. PMID 11356834.
- Engels N, Wollscheid B, Wienands J (2001). "Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha". Eur. J. Immunol. 31 (7): 2126–34. PMID 11449366.
- Sauer K, Liou J, Singh SB; et al. (2002). "Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes". J. Biol. Chem. 276 (48): 45207–16. doi:10.1074/jbc.M106811200. PMID 11487585.
- Engels N, Merchant M, Pappu R; et al. (2001). "Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling module". J. Exp. Med. 194 (3): 255–64. PMID 11489945.
- Tsuji S, Okamoto M, Yamada K; et al. (2001). "B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1". J. Exp. Med. 194 (4): 529–39. PMID 11514608.
- Kabak S, Skaggs BJ, Gold MR; et al. (2002). "The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways". Mol. Cell. Biol. 22 (8): 2524–35. PMID 11909947.
- Yasuda T, Tezuka T, Maeda A; et al. (2002). "Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells". J. Exp. Med. 196 (1): 51–63. PMID 12093870.
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