ADH7

Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
PDB rendering based on 1agn.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1agn​, 1d1s​, 1d1t​
Identifiers
Symbols	ADH7 ; ADH-4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37333
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide, also known as ADH7, is a human gene.

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members.

Further reading

• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xie P, Parsons SH, Speckhard DC; et al. (1997). "X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity". J. Biol. Chem. 272 (30): 18558–63. PMID 9228021.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yokoyama H, Baraona E, Lieber CS (1997). "Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH". Genomics. 31 (2): 243–5. doi:10.1006/geno.1996.0040. PMID 8824810.CS1 maint: Multiple names: authors list (link)
• Satre MA, Zgombić-Knight M, Duester G (1994). "The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene". J. Biol. Chem. 269 (22): 15606–12. PMID 8195208.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Yokoyama S, Matsuo Y, Ramsbotham R, Yokoyama R (1994). "Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7)". FEBS Lett. 351 (3): 411–5. PMID 8082805.CS1 maint: Multiple names: authors list (link)
• Yokoyama H, Baraona E, Lieber CS (1994). "Molecular cloning of human class IV alcohol dehydrogenase cDNA". Biochem. Biophys. Res. Commun. 203 (1): 219–24. doi:10.1006/bbrc.1994.2170. PMID 8074657.CS1 maint: Multiple names: authors list (link)
• Farrés J, Moreno A, Crosas B; et al. (1994). "Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships". Eur. J. Biochem. 224 (2): 549–57. PMID 7925371.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zgombić-Knight M, Foglio MH, Duester G (1995). "Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro". J. Biol. Chem. 270 (9): 4305–11. PMID 7876191.CS1 maint: Multiple names: authors list (link)
• Kedishvili NY, Bosron WF, Stone CL; et al. (1995). "Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes". J. Biol. Chem. 270 (8): 3625–30. PMID 7876099.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheung B, Anderson JK, Holmes RS, Beacham IR (1995). "Human stomach class IV alcohol dehydrogenase: molecular genetic analysis". Alcohol. Clin. Exp. Res. 19 (1): 185–6. PMID 7771649.CS1 maint: Multiple names: authors list (link)
• Parés X, Cederlund E, Moreno A; et al. (1992). "Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class". FEBS Lett. 303 (1): 69–72. PMID 1592118.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)