Hepatitis B historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor In Chief: Cafer Zorkun, M.D., Ph.D. [2]
Historical Perspective
The earliest record of an epidemic caused by hepatitis B virus was made by Lurman in 1885.[1] An outbreak of smallpox occurred in Bremen in 1883 and 1,289 shipyard employees were vaccinated with lymph from other people. After several weeks, and up to eight months later, 191 of the vaccinated workers became ill with jaundice and were diagnosed as suffering from serum hepatitis. Other employees who had been inoculated with different batches of lymph remained healthy. Lurman's paper, now regarded as a classical example of an epidemiological study, proved that contaminated lymph was the source of the outbreak. Later, numerous similar outbreaks were reported following the introduction, in 1909, of hypodermic needles that were used, and, more importantly, reused, for administering Salvarsan for the treatment of syphilis. The virus was not discovered until 1965 when Baruch Blumberg, then working at the National Institutes of Health (NIH), discovered the Australia antigen (later known to be hepatitis B surface antigen, or HBsAg) in the blood of Australian aboriginal people.[2] Although a virus had been suspected since the research published by MacCallum in 1947,[3] D.S. Dane and others discovered the virus particle in 1970 by electron microscopy.[4] By the early 1980s the genome of the virus had been sequenced,[5] and the first vaccines were being tested.[6]
References
- ↑ Lurman A (1885). "Eine icterus epidemic". Berl Klin Woschenschr (in German). 22: 20–3.
- ↑ Alter HJ, Blumberg BS (1966). "Further studies on a "new" human isoprecipitin system (Australia antigen)". Blood. 27 (3): 297–309. PMID 5930797. Retrieved 2012-02-08. Unknown parameter
|month=ignored (help) - ↑ MacCallum, F.O. (1947). "Homologous serum hepatitis". Lancet. 2: 691.
- ↑ Dane DS, Cameron CH, Briggs M (1970). "Virus-like particles in serum of patients with Australia-antigen-associated hepatitis". Lancet. 1 (7649): 695–8. PMID 4190997. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Galibert F, Mandart E, Fitoussi F, Tiollais P, Charnay P (1979). "Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli". Nature. 281 (5733): 646–50. PMID 399327. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ "Hepatitis B vaccine". Lancet. 2 (8206): 1229–30. 1980. PMID 6108398. Retrieved 2012-02-08. Unknown parameter
|month=ignored (help)