Dextro-transposition of the great arteries differential diagnosis

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Pre-natal dextro-transposition of the great arteries
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-In-Chief: Priyamvada Singh, MBBS [[2]]

Assistant Editor-In-Chief: Kristin Feeney, B.S. [[3]]


Patients with tricuspid atresia should be differentiated from other cardiac and non-cardiac causes of cyanosis-

Cardiac causes (starts with 't')-

  • Tetralogy of Fallot
  • Truncus arteriosus
  • Total anomalous pulmonary venous connection
  • Other tricuspid valve abnormalities like tricuspid regurgitaton, tricuspid stenosis

Other less common causes are- pulmonary atresia, hypoplastic left heart syndrome, anomalous systemic venous connection.


Non-cardiac causes


  • Pulmonary diseases - Structural abnormalities of the lung, V/P (ventilation-perfusion mismatch), airway obstruction, pneumothorax, and hypoventilation.
  • Abnormal hemoglobin like methemoglobin, polycythemia
  • Peripheral cyanosis for e.g. sepsis, hypoglycemia, dehydration, and hypoadrenalism.


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