Monkeypox history and symptoms

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Interim clinical, laboratory and epidemiologic criteria for case classification — U.S. Monkeypox Response, May 2022

Clinical and laboratory classification Criteria
Suspected New characteristic rash* OR
Meets one of the epidemiologic criteria and has high clinical suspicion† for monkeypox
Probable No suspicion of other recent orthopoxvirus exposure (e.g., Vaccinia virus in ACAM2000 vaccination) AND demonstration of the presence of
•     Orthopoxvirus DNA by polymerase chain reaction testing of a clinical specimen OR
•     Orthopoxvirus using immunohistochemical or electron microscopy testing methods

OR

•     Detectable levels of antiorthopoxvirus IgM antibody during the period of 4–56 days after rash onset
Confirmed Demonstration of the presence of Monkeypox virus DNA by polymerase chain reaction testing or next-generation sequencing of a clinical specimen

OR

Isolation of Monkeypox virus in culture from a clinical specimen

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