Cavernous angioma history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.

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Overview

  • Clinical symptoms of this disease include:
  • CCM can also be asymptomatic. Familial forms can present asymptomatically, however, when it becomes symptomatic, seizure is the most common symptom. [1]

History and Symptoms

  • This disease is characterized by grossly dilated blood vessels with a single layer of endothelium and an absence of neuronal tissue within the lesions.
  • These thinly-walled vessels resemble sinusoidal cavities filled with stagnant blood.
  • Blood vessels in patients with CCM can range from a few millimeters to several centimeters in diameter. CCM lesions commonly resemble raspberries in external structure.
  • Many patients live their whole life without knowing they have a cerebral cavernous malformation.
  • Other patients can have severe symptoms like seizures, headaches, paralysis, bleeding in the brain (cerebral hemorrhage, or hemorrhagic stroke), and even death.
  • The nature and severity of the symptoms depend on the lesion's location in the brain. Approximately 70% of these lesions occur in the supratentorial region of the brain.
  • The remaining 30% occur in the infratentorial region.

References

  1. Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL; et al. (2019). "Familial Cerebral Cavernous Malformations". Stroke. 50 (5): 1294–1301. doi:10.1161/STROKEAHA.118.022314. PMC 6924279 Check |pmc= value (help). PMID 30909834.