Chest pain natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aisha Adigun, B.Sc., M.D.[2]

Overview

If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

OR

Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].

OR

Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

Natural History, Complications, and Prognosis

Natural History

  • The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
  • The symptoms of (disease name) typically develop ___ years after exposure to ___.
  • If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

Complications

  • Common complications of [disease name] include:
    • [Complication 1]
    • [Complication 2]
    • [Complication 3]

Prognosis

  • Prognosis is generally good, 1-year mortality rate of patients presenting with chest pain is approximately 0.7%[1].
  • Depending on the etiology at the time of presentation, the prognosis may vary. However, the prognosis is generally regarded as good.
  • The presence of aortic dissection is associated with a particularly poor prognosis among patients presenting with chest pain with a 1-year mortality rate of 90%[2].
  • The 1-year mortality rate of patients with non-cardiac chest pain was found to be 2.3% compared with 7.2% in patients presenting with cardiac chest pain[3].

References

  1. Ilangkovan N, Mickley H, Diederichsen A, Lassen A, Sørensen TL, Sheta HM, Stæhr PB, Mogensen CB (December 2017). "Clinical features and prognosis of patients with acute non-specific chest pain in emergency and cardiology departments after the introduction of high-sensitivity troponins: a prospective cohort study". BMJ Open. 7 (12): e018636. doi:10.1136/bmjopen-2017-018636. PMC 5770919. PMID 29275346.
  2. [+https://www.msdmanuals.com/professional/cardiovascular-disorders/diseases-of-the-aorta-and-its-branches/aortic-dissection#:~:text=About%2020%25%20of%20patients%20with%20aortic%20dissection%20die%20before%20reaching,dissection%20and%2010%25%20for%20distal. "Aortic Dissection - Cardiovascular Disorders - MSD Manual Professional Edition"] Check |url= value (help).
  3. "Non-cardiac chest pain: prognosis and secondary healthcare utilisation | Open Heart".

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