Palmar plantar erythrodysesthesia natural history, complications, and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zain Fatiwala, M.D.

Overview

Initially, the patient of Palmar Plantar Erythrosysesthesia experiences a sensation of numbness/tingling in the palms and soles. This progresses into a painful, tingling, symmetric, well-demarcated swelling with an erythematous plaques. It is followed by a phase of desquamation upon resolution.

Natural History

Initially, the patient of Palmar Plantar Erythrosysesthesia experiences a sensation of numbness/tingling in the palms and soles. This progresses into a painful, tingling, symmetric, well-demarcated swelling with an erythematous plaques. It is followed by a phase of desquamation upon resolution.

One of the complications associated with PPE is loss of fingerprints. It is documented in a patient who was treated with capecitabine and detained at an airport while travelling because of lack of finger prints.

Prognosis

PPE variably recurs with resumption of chemotherapy. Long-term chemotherapy may also result in reversible palmoplantar keratoderma. Symptoms resolve 1-2 weeks after cessation of chemotherapy (Apisarnthanarax and Duvic 2003).