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Splenomegaly differential:

Diseases Symptoms Signs/Physical Exam Labs Imaging Standard Diagnostic Test
Fatigue Fever SOB Dark urine Weight loss Jaundice Ascites JVP Fe studies LFTs Peripheral smear
Portal vein thrombosis
CHF
Cirrhosis
Hemolysis
Chronic anemia
Malaria (Infections)
Sarcoidosis
Amyloidosis
Thalassemia
Gaucher/Niemann-Pick disease
Leukemia
Lymphoma
Myeloproliferative disorders