Diaphragmatic paralysis other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

There are no other diagnostic studies associated with [disease name].

OR

[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].

OR

Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

Pulmonary function test:

  • Spirometry in the supine and sitting positions may be helpful in the diagnosis of diaphragmatic paralysis. Findings suggestive of diaphragmatic paralysis include:
    • Unilateral diaphragmatic paralysis:
      • Mild decrease in vital capacity (VC): 75% of the predicted value and further decrease (10% to 20% in the supine position) [1]
      • Functional residual capacity (FRC) and total lung capacity (TLC) are usually unchanged. [2]
    • Bilateral diaphragmatic paralysis:
      • Decrease in vital capacity (VC): 50 % of the predicted value and further decrease (30% to 50% in the supine position )[3]
      • Total lung capacity may be reduced
      • Residual volume (RV) may be elevated[4]

Lung function testing is frequently performed as a first-line test to assess and quantify the physiological impact of diaphragm weakness. Unilateral diaphragm weakness is usually associated with a mild decrease in vital capacity (VC), to approximately 75% of the predicted value [86,105], with a further 10% to 20% decrease in the supine position [105], while functional residual capacity (FRC) and total lung capacity (TLC) are usually preserved [86,105]. In bilateral diaphragm weakness, VC usually reaches mean values of approximately 50% predicted and can further decrease by 30% to 50% when supine [90]. TLC can also be reduced, while residual volume (RV) can be elevated [111]. Of note, the magnitude of the fall in VC in the supine position has been shown to be correlated to Pdi,sn in this population [111].

  • [Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include:
    • [Finding 1]
    • [Finding 2]
    • [Finding 3]
  • Other diagnostic studies for [disease name] include:
    • [Diagnostic study 1], which demonstrates:
      • [Finding 1]
      • [Finding 2]
      • [Finding 3]
    • [Diagnostic study 2], which demonstrates:
      • [Finding 1]
      • [Finding 2]
      • [Finding 3]

References

  1. Lisboa C, Paré PD, Pertuzé J, Contreras G, Moreno R, Guillemi S, Cruz E (September 1986). "Inspiratory muscle function in unilateral diaphragmatic paralysis". Am. Rev. Respir. Dis. 134 (3): 488–92. doi:10.1164/arrd.1986.134.3.488. PMID 3752705.
  2. Lisboa C, Paré PD, Pertuzé J, Contreras G, Moreno R, Guillemi S, Cruz E (September 1986). "Inspiratory muscle function in unilateral diaphragmatic paralysis". Am. Rev. Respir. Dis. 134 (3): 488–92. doi:10.1164/arrd.1986.134.3.488. PMID 3752705.
  3. Laroche CM, Carroll N, Moxham J, Green M (October 1988). "Clinical significance of severe isolated diaphragm weakness". Am. Rev. Respir. Dis. 138 (4): 862–6. doi:10.1164/ajrccm/138.4.862. PMID 3202460.
  4. Mier-Jedrzejowicz A, Brophy C, Moxham J, Green M (April 1988). "Assessment of diaphragm weakness". Am. Rev. Respir. Dis. 137 (4): 877–83. doi:10.1164/ajrccm/137.4.877. PMID 3354995.

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