SEMA5A

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.[1][2][3]

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM][3]

Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016).

References

  1. Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev. 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451.
  2. Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
  3. 3.0 3.1 "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".

Further reading