SLC8B1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 is a protein that in humans is encoded by the SLC8B1 gene.

Function

SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]. ##Evidence-Data-START## CDS exon combination :: BC098360.1, AY601759.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END##

Further reading

• Boyman, L.; Williams, G. S. B.; Khananshvili, D.; Sekler, I.; Lederer, W. J. (2013). "NCLX: The mitochondrial sodium calcium exchanger". Journal of Molecular and Cellular Cardiology. 59: 205–213. doi:10.1016/j.yjmcc.2013.03.012. PMC 3951392. PMID 23538132.
• Palty, R.; Ohana, E.; Hershfinkel, M.; Volokita, M.; Elgazar, V.; Beharier, O.; Silverman, W. F.; Argaman, M.; Sekler, I. (2004). "Lithium-Calcium Exchange is Mediated by a Distinct Potassium-independent Sodium-Calcium Exchanger". Journal of Biological Chemistry. 279 (24): 25234–25240. doi:10.1074/jbc.M401229200. PMID 15060069.
• Aslibekyan, S.; An, P.; Frazier-Wood, A. C.; Kabagambe, E. K.; Irvin, M. R.; Straka, R. J.; Tiwari, H. K.; Tsai, M. Y.; Hopkins, P. N.; Borecki, I. B.; Ordovas, J. M.; Arnett, D. K. (2013). "Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network". Nutrition, Metabolism and Cardiovascular Diseases. 23 (10): 987–994. doi:10.1016/j.numecd.2012.07.010. PMC 3578131. PMID 23149075.
• Cai, X.; Lytton, J. (2003). "Molecular Cloning of a Sixth Member of the K+-dependent Na+/Ca2+ Exchanger Gene Family, NCKX6". Journal of Biological Chemistry. 279 (7): 5867–5876. doi:10.1074/jbc.M310908200. PMID 14625281.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.