SLIT2

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Slit homolog 2 protein is a protein that in humans is encoded by the SLIT2 gene.

Interactions

SLIT2 has been shown to interact with Glypican 1.

Further reading

• Wong K; Park HT; Wu JY; Rao Y (2003). "Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes". Curr. Opin. Genet. Dev. 12 (5): 583–91. doi:10.1016/S0959-437X(02)00343-X. PMID 12200164.
• Zhao XC; Zhang LM; Li Q; Tong DY; Fan LC; An P; Wu XY; Chen WM; Zhao P; Wang J. (2013). "Isoflurane post-conditioning protects primary cultures of cortical neurons against oxygen and glucose deprivation injury via upregulation of Slit2/Robo1". Brain Res. 1537: 283–9. doi:10.1016/j.brainres.2013.08.036. PMC 3820100. PMID 23994690.
• Wang KH, Brose K, Arnott D, et al. (1999). "Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching". Cell. 96 (6): 771–84. doi:10.1016/S0092-8674(00)80588-7. PMID 10102266.
• Brose K, Bland KS, Wang KH, et al. (1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance". Cell. 96 (6): 795–806. doi:10.1016/S0092-8674(00)80590-5. PMID 10102268.
• Li HS, Chen JH, Wu W, et al. (1999). "Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons". Cell. 96 (6): 807–18. doi:10.1016/S0092-8674(00)80591-7. PMID 10102269.
• Nguyen Ba-Charvet KT, Brose K, Marillat V, et al. (1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons". Neuron. 22 (3): 463–73. doi:10.1016/S0896-6273(00)80702-3. PMID 10197527.
• Holmes GP, Negus K, Burridge L, et al. (1999). "Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis". Mech. Dev. 79 (1–2): 57–72. doi:10.1016/S0925-4773(98)00174-9. PMID 10349621.
• Liang Y, Annan RS, Carr SA, et al. (1999). "Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain". J. Biol. Chem. 274 (25): 17885–92. doi:10.1074/jbc.274.25.17885. PMID 10364234.
• Wu W, Wong K, Chen J, et al. (1999). "Directional guidance of neuronal migration in the olfactory system by the protein Slit". Nature. 400 (6742): 331–6. doi:10.1038/22477. PMC 2041931. PMID 10432110.
• Georgas K, Burridge L, Smith K, et al. (2000). "Assignment of the human slit homologue SLIT2 to human chromosome band 4p15.2". Cytogenet. Cell Genet. 86 (3–4): 246–7. doi:10.1159/000015351. PMID 10575218.
• Niclou SP; Jia L; Raper JA (2000). "Slit2 is a repellent for retinal ganglion cell axons". J. Neurosci. 20 (13): 4962–74. PMID 10864954.
• Zou Y; Stoeckli E; Chen H; Tessier-Lavigne M (2000). "Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord". Cell. 102 (3): 363–75. doi:10.1016/S0092-8674(00)00041-6. PMID 10975526.
• Chen JH, Wen L, Dupuis S, et al. (2001). "The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons". J. Neurosci. 21 (5): 1548–56. PMID 11222645.
• Stein E; Tessier-Lavigne M (2001). "Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex". Science. 291 (5510): 1928–38. doi:10.1126/science.1058445. PMID 11239147.
• Wu JY, Feng L, Park HT, et al. (2001). "The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors". Nature. 410 (6831): 948–52. doi:10.1038/35073616. PMC 2072862. PMID 11309622.
• Ronca F; Andersen JS; Paech V; Margolis RU (2001). "Characterization of Slit protein interactions with glypican-1". J. Biol. Chem. 276 (31): 29141–7. doi:10.1074/jbc.M100240200. PMID 11375980.
• Nguyen Ba-Charvet KT, Brose K, Ma L, et al. (2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance". J. Neurosci. 21 (12): 4281–9. PMID 11404413.
• Little M, Rumballe B, Georgas K, et al. (2003). "Conserved modularity and potential for alternate splicing in mouse and human Slit genes". Int. J. Dev. Biol. 46 (4): 385–91. PMID 12141424.
• Dallol A, Da Silva NF, Viacava P, et al. (2002). "SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers". Cancer Res. 62 (20): 5874–80. PMID 12384551.