Osteochondroma causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

There are no established direct causes for osteochondroma. The development of hereditary multiple osteochondroma may be the result of multiple genetic mutations.[1]

Causes

  • There are no established direct causes for osteochondroma.[2]
  • The development of hereditary multiple osteochondroma may be the result of multiple genetic mutations.[1]
  • The related genetic mutations, include:
  • Germ line mutation in EXT1 gene located on chromosome 8q24.11-q24.13
  • Germ line mutation in EXT2 gene located on chromosome 11p11-12

References

  1. 1.0 1.1 Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M (2008). "Osteochondromas: review of the clinical, radiological and pathological features". In Vivo (Athens, Greece). 22 (5): 633–46. PMID 18853760.
  2. Osteochondromas/Osteocartilaginous exostosis." Wheeless Textbook of Anatomy, 1996. CR Wheeless. Duke University Medical Center

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