Biliary cystadenoma and cystadenocarcinoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Neoplastic transformation is the most common complication of biliary cystadenoma. Biliary cystadenoma with mesenchymal stroma is associated with most favorable prognosis.

Complications

  • In fact, even if the cystadenoma is a benign neoplasm, it has a high rate of recurrence and a potential for neoplastic transformation.
  • Malignant transformation rate can be as high as 30%.[1]

Prognosis

Although biliary cystadenomas are benign tumors, they may recur after excision and have potential to develop into biliary cystadenocarcinomas.[2]

Biliary cystadenoma

  • The prognosis of completely removed billiary cystadenomas is excellent, recurrence is rare.[3]
  • Cystadenomas with mesenchymal stroma are considered premalignant with a good prognosis while those without are known to transform to malignancy more often with a poor prognosis.[4]

Biliary cystadenocarcinoma

  • When treated with radical excision biliary cystadenocarcinomas have good prognosis, particularly those with mesenchymal stroma, unless the tumor invades the adjacent liver tissue or neighboring organs, or metastases are present.[3]
  • Biliary cystadenocarcinomas in men which are not associated with mesenchymal stroma have worse prognosis, even after complete excision.[3]

References

  1. Ramacciato, Giovanni; Nigri, Giuseppe R; D'Angelo, Francesco; Aurello, Paolo; Bellagamba, Riccardo; Colarossi, Cristina; Pilozzi, Emanuela; Del Gaudio, Massimo (2006). World Journal of Surgical Oncology. 4 (1): 76. doi:10.1186/1477-7819-4-76. ISSN 1477-7819. Missing or empty |title= (help)
  2. Biliary cystadenoma.Dr Yuranga Weerakkody and Radswiki et al.Radiopaedia.org 2015. http://radiopaedia.org/articles/biliary-cystadenoma
  3. 3.0 3.1 3.2 Chandrasekar, G. (2015), Biliary Cystadenoma of Liver. (PDF), Chennai: Stanley Medical Journal, p. 37-42, retrieved December 10, 2015
  4. Ahanatha Pillai, Sastha; Velayutham, Vimalraj; Perumal, Senthilkumar; Ulagendra Perumal, Srinivasan; Lakshmanan, Anand; Ramaswami, Sukumar; Ramasamy, Ravi; Sathyanesan, Jeswanth; Palaniappan, Ravichandran; Rajagopal, Surendran (2012). "Biliary Cystadenomas: A Case for Complete Resection". HPB Surgery. 2012: 1–6. doi:10.1155/2012/501705. ISSN 0894-8569.

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