Linitis plastica screening

Jump to navigation Jump to search

Linitis plastica Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Linitis plastica from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Staging

Diagnostic study of choice

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Linitis plastica screening On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Linitis plastica screening

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Linitis plastica screening

CDC on Linitis plastica screening

Linitis plastica screening in the news

Blogs on Linitis plastica screening

Directions to Hospitals Treating Linitis plastica

Risk calculators and risk factors for Linitis plastica screening

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Patients who have a relative with hereditary diffuse gastric adenocarcinoma (HDGC) should be screened earlier for CDH1 gene mutations.[1]

Screening

  • Patients who have a relative with hereditary diffuse gastric adenocarcinoma (HDGC) should be screened earlier for CDH1 gene mutations.[1]
  • Indication for prophylactic gastrectomy include CDH1 positive patients.[2]
    • The disease penetrance for the hereditary form is 80%, resulting in a very high risk of developing the cancer.

References

  1. 1.0 1.1 Hereditary diffuse gastric cancer. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/hereditary-diffuse-gastric-cancer#definition Accessed on December 10, 2015
  2. Pandalai PK, Lauwers GY, Chung DC, Patel D, Yoon SS (2011). "Prophylactic total gastrectomy for individuals with germline CDH1 mutation". Surgery. 149 (3): 347–55. doi:10.1016/j.surg.2010.07.005. PMID 20719348.


Template:WikiDoc Sources