Sandbox subdural empyema

Antimicrobial Regimen – Empiric Therapy

• Ampicillin 200 mg/kg/day IV q4h AND
• Cefotaxime 200 mg/kg/day IV q6h

• Ampicillin 200 mg/kg/day IV q4h AND
• Cefotaxime 200 mg/kg/day IV q6h OR Ceftriaxone 100 mg/kg/day IV q12h

• Vancomycin 60 mg/kg/day IV q6h (pediatric) or 2 g/day IV q12h (adult) AND
• Cefotaxime 200 mg/kg/day IV q6h (pediatric) or 12 g/day IV q4h (adult) OR Ceftriaxone 100 mg/kg/day IV q12h (pediatric) or 4 g/day IV q12h (adult) OR Cefepime 150 mg/kg/day IV q8h (pediatric) or 6 g/day IV q8h (adult)

• Ampicillin 200 mg/kg/day IV q4h AND
• Vancomycin 2 g/day IV q12h AND
• Cefotaxime 12 g/day IV q4h OR Ceftriaxone 4 g/day IV q12h OR Cefepime 6 g/day IV q8h

• Ampicillin 200 mg/kg/day IV q4h (pediatric) or 12 g/day IV q4h (adult) AND
• Vancomycin 60 mg/kg/day IV q6h (pediatric) or 2 g/day IV q12h (adult) AND
• Ceftazidime 150 mg/kg/day IV q8h (pediatric) or 6 g/day IV q8h (adult) OR Meropenem 20 mg/kg/day IV q8h (pediatric) or 3 g/day IV q8h (adult)