Osteosarcoma differential diagnosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].
Overview
Osteosarcoma must be differentiated from other diseases such as: any type of bone lesions caused by infection and/or tumors. Features such as the eccentric location of the tumor in the metaphyseal portion of the bone and the skeletal location help to distinguish osteosarcoma from Ewing sarcoma. Bone metastases from other primary tumours, less frequent in the young than in adult patients, should also be considered.
Differentiating Osteosarcoma from other Diseases
Osteosarcoma must be differentiated from:Osteomyelitis, Pediatric Osteomyelitis, Rhabdomyosarcoma, Pediatric Rhabdomyosarcoma, Chondrosarcoma, Metastases from other malignancies, Fibrous dysplasia, Giant cell tumors, Ewing's sarcoma, Malignant fibrous histiocytoma, LymphomaOsteoblastoma, Aneurysmal bone cyst, Fibrosarcoma and Cortical desmoid.
Disease | Bone involvement | Bone pain | Fever | Fractures | Mechanism | ALK level | Diagnosis |
---|---|---|---|---|---|---|---|
Osteoblastoma | Single | Yes | No | Yes | Neoplasm | High | Radiology and biopsy |
Osteosarcoma | Single | Yes | No | Yes | Neoplasm | Normal | Radiology and biopsy |
Osteoid osteoma | Single | Yes | No | Yes | Neoplasm | High | Radiology and biopsy |
Aneurysmal bone cyst | Single | Yes | No | No | Neoplasm | High | Radiology and biopsy |
Stress fracture | Multiple | Yes | No | Yes | Stress | Normal | Radiology |
Osteomyelitis | Single | Yes | Yes | No | Infection | Normal | Radiology and biopsy |
Brodie's abscess | Single | Yes | Yes | No | Infection | Normal | Radiology and biopsy |