DPP6

Dipeptidyl-peptidase 6
PDB rendering based on 1xfd.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1xfd​
Identifiers
Symbols	DPP6 ; DPPX; MGC46605
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22560
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Dipeptidyl-peptidase 6, also known as DPP6, is a human gene.

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Wada K, Yokotani N, Hunter C; et al. (1992). "Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 197–201. PMID 1729689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adams MD, Kerlavage AR, Fleischmann RD; et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yokotani N, Doi K, Wenthold RJ, Wada K (1993). "Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7". Hum. Mol. Genet. 2 (7): 1037–9. PMID 8103397.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
• Kin Y, Misumi Y, Ikehara Y (2001). "Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein". J. Biochem. 129 (2): 289–95. PMID 11173531.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nadal MS, Ozaita A, Amarillo Y; et al. (2003). "The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels". Neuron. 37 (3): 449–61. PMID 12575952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmitt-Ulms G, Hansen K, Liu J; et al. (2005). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nat. Biotechnol. 22 (6): 724–31. doi:10.1038/nbt969. PMID 15146195.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strop P, Bankovich AJ, Hansen KC; et al. (2004). "Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family". J. Mol. Biol. 343 (4): 1055–65. doi:10.1016/j.jmb.2004.09.003. PMID 15476821.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zagha E, Ozaita A, Chang SY; et al. (2005). "DPP10 modulates Kv4-mediated A-type potassium channels". J. Biol. Chem. 280 (19): 18853–61. doi:10.1074/jbc.M410613200. PMID 15671030.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Radicke S, Cotella D, Graf EM; et al. (2005). "Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3". J. Physiol. (Lond.). 565 (Pt 3): 751–6. doi:10.1113/jphysiol.2005.087312. PMID 15890703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ren X, Hayashi Y, Yoshimura N, Takimoto K (2005). "Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels". Mol. Cell. Neurosci. 29 (2): 320–32. doi:10.1016/j.mcn.2005.02.003. PMID 15911355.CS1 maint: Multiple names: authors list (link)
• Jerng HH, Kunjilwar K, Pfaffinger PJ (2006). "Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties". J. Physiol. (Lond.). 568 (Pt 3): 767–88. doi:10.1113/jphysiol.2005.087858. PMID 16123112.CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nadal MS, Amarillo Y, Vega-Saenz de Miera E, Rudy B (2006). "Differential characterization of three alternative spliced isoforms of DPPX". Brain Res. 1094 (1): 1–12. doi:10.1016/j.brainres.2006.03.106. PMID 16764835.CS1 maint: Multiple names: authors list (link)