PDGFC

Platelet derived growth factor C
Identifiers
Symbols	PDGFC ; SCDGF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9423
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PDGFC 218718 at tn.png
File:PBB GE PDGFC gnf1h09218 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Platelet derived growth factor C, also known as PDGFC, is a human gene.

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain.

Further reading

• Li X, Pontén A, Aase K; et al. (2000). "PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor". Nat. Cell Biol. 2 (5): 302–9. doi:10.1038/35010579. PMID 10806482.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hamada T, Ui-Tei K, Miyata Y (2000). "A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family". FEBS Lett. 475 (2): 97–102. PMID 10858496.CS1 maint: Multiple names: authors list (link)
• Tsai YJ, Lee RK, Lin SP, Chen YH (2000). "Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract". Biochim. Biophys. Acta. 1492 (1): 196–202. PMID 11004490.CS1 maint: Multiple names: authors list (link)
• Gilbertson DG, Duff ME, West JW; et al. (2001). "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor". J. Biol. Chem. 276 (29): 27406–14. doi:10.1074/jbc.M101056200. PMID 11297552.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zwerner JP, May WA (2001). "PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors". Oncogene. 20 (5): 626–33. doi:10.1038/sj.onc.1204133. PMID 11313995.
• Uutela M, Laurén J, Bergsten E; et al. (2001). "Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes". Circulation. 103 (18): 2242–7. PMID 11342471.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zwerner JP, May WA (2002). "Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines". Oncogene. 21 (24): 3847–54. doi:10.1038/sj.onc.1205486. PMID 12032822.
• Andrae J, Molander C, Smits A; et al. (2002). "Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells". Biochem. Biophys. Res. Commun. 296 (3): 604–11. PMID 12176024.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reigstad LJ, Sande HM, Fluge Ø; et al. (2003). "Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure". J. Biol. Chem. 278 (19): 17114–20. doi:10.1074/jbc.M301728200. PMID 12598536.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eitner F, Ostendorf T, Kretzler M; et al. (2003). "PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases". J. Am. Soc. Nephrol. 14 (5): 1145–53. PMID 12707385.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fang L, Yan Y, Komuves LG; et al. (2004). "PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle". Arterioscler. Thromb. Vasc. Biol. 24 (4): 787–92. PMID 15061151.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jinnin M, Ihn H, Mimura Y; et al. (2005). "Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts". J. Cell. Physiol. 202 (2): 510–7. doi:10.1002/jcp.20154. PMID 15389578.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Campbell JS, Hughes SD, Gilbertson DG; et al. (2005). "Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma". Proc. Natl. Acad. Sci. U.S.A. 102 (9): 3389–94. doi:10.1073/pnas.0409722102. PMID 15728360.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fredriksson L, Ehnman M, Fieber C, Eriksson U (2005). "Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator". J. Biol. Chem. 280 (29): 26856–62. doi:10.1074/jbc.M503388200. PMID 15911618.CS1 maint: Multiple names: authors list (link)
• Reigstad LJ, Martinez A, Varhaug JE, Lillehaug JR (2006). "Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines". Exp. Cell Res. 312 (6): 782–95. doi:10.1016/j.yexcr.2005.11.035. PMID 16443219.CS1 maint: Multiple names: authors list (link)