Diabetic nephropathy medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The goals of treatment are to slow the progression of kidney damage and control related complications. The main treatment, once proteinuria is established, is ACE inhibitor drugs, which usually reduces glomerular hypertension, proteinuria levels, systemic hypertension and slows the progression of diabetic nephropathy.

Medical Therapy

Dialysis may be necessary once end-stage renal disease develops. At this stage, a kidney transplantation must be considered. Another option for type 1 diabetes patients is a combined kidney-pancreas transplant. C-peptide, a by-product of insulin production, may provide new hope for patients sufering from diabetic nephropathy [1] [2].

Drug interaction

Patients with diabetic nephropathy should avoid taking the following drugs:

References

  1. C-peptide is a bioactive peptide. [Diabetologia. 2007] - PubMed Result
  2. Wahren J, Ekberg K, Jörnvall H (2007). "C-peptide is a bioactive peptide". Diabetologia. 50 (3): 503–9. doi:10.1007/s00125-006-0559-y. PMID 17235526.

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