Magnesium sulfate (injection): Difference between revisions

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__NOTOC__
{{DrugProjectFormSinglePage
|authorTag=


{{Magnesium sulfate}}
Gerald Chi


{{Chembox new
<!--Overview-->
|   Name = Magnesium sulfate
 
|   ImageFile = Magnesium sulfate anhydrous.jpg
|genericName=
|   ImageSize = 200px
 
|   ImageName = Anhydrous magnesium sulfate
 
|   IUPACName = Magnesium sulfate (anhydrous);  Magnesium sulfate heptahydrate
 
|   OtherNames = Epsom salts; bitter salts
|aOrAn=
| Section1 = {{Chembox Identifiers
 
|  CASNo = 7487-88-9
a
|   EINECS =  
 
|  RTECS =
|drugClass=
  }}
 
| Section2 = {{Chembox Properties
 
|   Formula = MgSO<sub>4</sub> (anhydrous);
 
MgSO<sub>4</sub>&middot;7H<sub>2</sub>O
|indication=
|   Appearance = white crystalline solid
 
|   Density = 2.66g/mL</sup>, solid
 
|   MolarMass = 120.415 g
 
|   Solubility = 25.5 g/100 ml (20 °C)
|hasBlackBoxWarning=
|   MeltingPt = 1124°C ''decomp.''
 
  }}
Yes
| Section3 = {{Chembox Structure
 
|   Coordination =  
|adverseReactions=
|   CrystalStruct = [[monoclinic]] (hydrate)
 
  }}
 
| Section8 = {{Chembox Related
 
|   OtherCations = [[Calcium sulfate]]; [[Aluminium sulfate]]
<!--Black Box Warning-->
|   OtherCpds =}}
 
}}
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<!--Adult Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Adult)-->
 
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=====Condition1=====
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
* Dosing Information
 
:* Dosage
 
=====Condition3=====
 
* Dosing Information
 
:* Dosage
 
=====Condition4=====
 
* Dosing Information
 
:* Dosage
 
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|offLabelAdultGuideSupport=
 
=====Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
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|offLabelAdultNoGuideSupport=
 
=====Condition1=====
 
* Dosing Information
 
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=====Condition2=====
 
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<!--Pediatric Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
 
|fdaLIADPed=
 
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* Dosing Information
 
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<!--Guideline-Supported Use (Pediatric)-->
 
|offLabelPedGuideSupport=
 
=====Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
:* Dosage
 
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<!--Non–Guideline-Supported Use (Pediatric)-->
 
|offLabelPedNoGuideSupport=
 
=====Condition1=====
 
* Dosing Information
 
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|contraindications=
 
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|warnings=
 
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=====Body as a Whole=====
 
 
 
=====Cardiovascular=====
 
 
 
=====Digestive=====
 
 
 
=====Endocrine=====
 
 
 
=====Hematologic and Lymphatic=====
 
 
 
=====Metabolic and Nutritional=====
 
 
 
=====Musculoskeletal=====
 
 
 
=====Neurologic=====
 
 
 
=====Respiratory=====
 
 
 
=====Skin and Hypersensitivy Reactions=====
 
 
 
=====Special Senses=====
 
 
 
=====Urogenital=====
 
 
 
=====Miscellaneous=====
 
 
 
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* Oral
 
* Intravenous
 
|monitoring=
 
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=====Condition1=====
 
* Description
 
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|IVCompat=
 
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<!--Overdosage-->
 
|overdose=
 
===Acute Overdose===
 
====Signs and Symptoms====
 
* Description
 
====Management====
 
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|alcohol=
 
* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
 
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* ®<ref>{{Cite web | title =  | url =  }}</ref>
 
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{{CMG}}; {{AE}} {{AZ}}
|lookAlike=


'''''For patient information, click <u>[[Magnesium sulfate (patient information)|here]]'''''</u>.
* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>


{{SB}} Magnesium sulfate
<!--Drug Shortage Status-->


==Overview==
|drugShortage=
'''Magnesium sulfate''' (or magnesium sulphate) is an [[inorganic]] [[salt (chemistry)|salt]] ([[chemical compound]]) containing [[magnesium]], [[sulfur]] and [[oxygen]], with the formula MgSO<sub>4</sub>. It is often encountered as the heptahydrate [[sulfate mineral]] [[epsomite]] (MgSO<sub>4</sub>·7H<sub>2</sub>O), commonly called '''Epsom salt''', taking its name from a bitter saline spring in [[Epsom]] in [[Surrey]], England, where the salt was produced from the springs that arise where the porous chalk of the [[North Downs]] meets non-porous London clay. The monohydrate, MgSO<sub>4</sub>·H<sub>2</sub>O is found as the mineral [[kieserite]]. The overall global annual usage in the mid 1970s of the monohydrate was 2.3 million tons, of which the majority as used in agriculture.<ref>Industrial Inorganic Chemistry, Karl Heinz Büchel, Hans-Heinrich Moretto, Dietmar Werner, John Wiley & Sons, 2d edition, 2000, ISBN 9783527613335</ref>
}}


==Category==
<!--Pill Image-->
Purgative Laxative and [[Antiarrhythmic agent|Antiarrythmics]]


==FDA Package Insert<ref name="dailymed.nlm.nih.gov">{{Cite web  | last = | first = | title = MAGNESIUM SULFATE (MAGNESIUM SULFATE HEPTAHYDRATE) INJECTION, SOLUTION [PHYSICIANS TOTAL CARE, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=70f46528-7a1c-48e7-9f0f-7e920e708d63 | publisher = | date = | accessdate = }}</ref>==
{{PillImage
|fileName=No image.jpg|This image is provided by the National Library of Medicine.
|drugName=
|NDC=
|drugAuthor=
|ingredients=
|pillImprint=
|dosageValue=
|dosageUnit=
|pillColor=
|pillShape=
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|pillScore=
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'''| [[Magnesium sulfate indications and usage|Indications and Usage]]'''
<!--Label Display Image-->
'''| [[Magnesium sulfate dosage and administration|Dosage and Administration]]'''
'''| [[Magnesium sulfate dosage forms and strengths|Dosage Forms and Strengths]]'''
'''| [[Magnesium sulfate contraindications|Contraindications]]'''
'''| [[Magnesium sulfate warnings|Warnings and Precautions]]'''
'''| [[Magnesium sulfate adverse reactions|Adverse Reactions]]'''
'''| [[Magnesium sulfate drug interactions|Drug Interactions]]'''
'''| [[Magnesium sulfate use in specific populations|Use in Specific Populations]]'''
'''| [[Magnesium sulfate overdosage|Overdosage]]'''
'''| [[Magnesium sulfate description|Description]]'''
'''| [[Magnesium sulfate clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Magnesium sulfate nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Magnesium sulfate clinical studies|Clinical Studies]]'''
'''| [[Magnesium sulfate how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Magnesium sulfate patient counseling information|Patient Counseling Information]]'''
'''| [[Magnesium sulfate labels and packages|Labels and Packages]]'''


==Mechanism of Action==
{{LabelImage
Magensium has a role factor in more than 300 enzymatic reactions. It is involved in many processes as hormone receptor binding, gating of calcium channels, transmembrane ion flux and regulation of adenylate cyclase. It has role in muscle contraction, vasomotor tone, cardiac excitability and neural activity.<ref>{{Cite web  | last = | first =  | title = http://bja.oxfordjournals.org/content/83/2/302.full.pdf | url = http://bja.oxfordjournals.org/content/83/2/302.full.pdf | publisher =  | date =  | accessdate = }}</ref>
|fileName={{PAGENAME}}11.png|This image is provided by the National Library of Medicine.
}}


==References==
{{LabelImage
|fileName={{PAGENAME}}11.png|This image is provided by the National Library of Medicine.
}}


{{Reflist|2}}
<!--Category-->


[[Category:Drugs]]
[[Category:Cardiovascular Drugs]]
[[Category:Drug]]

Revision as of 22:09, 10 July 2014

Magnesium sulfate (injection)
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gerald Chi

Disclaimer

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Black Box Warning

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Magnesium sulfate (injection) is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Magnesium sulfate (injection) in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Magnesium sulfate (injection) in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Magnesium sulfate (injection) in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Magnesium sulfate (injection) in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Magnesium sulfate (injection) in pediatric patients.

Contraindications

  • Condition1

Warnings

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Magnesium sulfate (injection) in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Magnesium sulfate (injection) in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Magnesium sulfate (injection) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Magnesium sulfate (injection) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Magnesium sulfate (injection) with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Magnesium sulfate (injection) with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Magnesium sulfate (injection) with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Magnesium sulfate (injection) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Magnesium sulfate (injection) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Magnesium sulfate (injection) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Magnesium sulfate (injection) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Magnesium sulfate (injection) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Magnesium sulfate (injection) in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Magnesium sulfate (injection) in the drug label.

Condition1
  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Magnesium sulfate (injection) in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Magnesium sulfate (injection) in the drug label.

Pharmacology

There is limited information regarding Magnesium sulfate (injection) Pharmacology in the drug label.

Mechanism of Action

Structure

File:Magnesium sulfate (injection)01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Magnesium sulfate (injection) in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Magnesium sulfate (injection) in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Magnesium sulfate (injection) in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Magnesium sulfate (injection) in the drug label.

Condition1
  • Description

How Supplied

Storage

There is limited information regarding Magnesium sulfate (injection) Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Magnesium sulfate (injection) |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Magnesium sulfate (injection) |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Magnesium sulfate (injection) in the drug label.

Precautions with Alcohol

  • Alcohol-Magnesium sulfate (injection) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)


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