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| ==Random notes== | | ==Random notes== |
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| ===Acute Pharmacotherapy===
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| Until the development of [[dapsone]], [[rifampin]], and [[clofazimine]] in the 1940s, there was no effective cure for leprosy. However, dapsone is only weakly bactericidal against ''[[M. leprae]]'' and it was considered necessary for patients to take the drug indefinitely. Moreover, when dapsone was used alone, the ''M. leprae'' population quickly [[evolution|evolved]] [[antibiotic resistance]]; by the 1960s, the world's only known anti-leprosy drug became virtually useless.
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| The search for more effective anti-leprosy drugs to dapsone led to the use of clofazimine and rifampicin in the 1960s and 1970s.<ref name=Rees_1970>{{cite journal | author= Rees RJ, Pearson JM, Waters MF | title=Experimental and clinical studies on rifampicin in treatment of leprosy | journal=Br Med J | year=1970 | pages=89-92 | volume= 688 | issue= 1 | pmid=4903972}}</ref> Later, Shantaram Yawalkar and colleagues formulated a combined therapy using rifampicin and dapsone, intended to mitigate bacterial resistance.<ref name=Yawalkar_1982>{{cite journal | author=Yawalkar SJ, McDougall AC, Languillon J, Ghosh S, Hajra SK, Opromolla DV, Tonello CJ | title=Once-monthly rifampicin plus daily dapsone in initial treatment of lepromatous leprosy | journal=Lancet | year=1982 | pages=1199-1202 | volume= 8283 | issue= 1 | pmid = 6122970}}</ref> Multidrug therapy (MDT) and combining all three drugs was first recommended by a WHO Expert Committee in 1981. These three anti-leprosy drugs are still used in the standard MDT regimens. None of them are used alone because of the risk of developing resistance.
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| Because this treatment is quite expensive, it was not quickly adopted in most endemic countries. In 1985 leprosy was still considered a public health problem in 122 countries. The 44th World Health Assembly (WHA), held in Geneva in 1991 passed a resolution to eliminate leprosy as a public health problem by the year 2000 — defined as reducing the global [[prevalence]] of the disease to less than 1 case per 100,000. At the Assembly, the World Health Organization (WHO) was given the mandate to develop an elimination strategy by its member states, based on increasing the geographical coverage of MDT and patients’ accessibility to the treatment.
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| The WHO Study Group's report on the ''Chemotherapy of Leprosy'' in 1993 recommended two types of standard MDT regimen be adapted.<ref name=WHO_1993>{{cite web | title = Chemotherapy of Leprosy | work = WHO Technical Report Series 847 | publisher = WHO | date = 1994 | url = http://www.who.int/lep/mdt/chemotherapy/en/index.html | accessdate = 2007-03-24}}</ref> The first was a 24-month treatment for multibacillary (MB or lepromatous) cases using rifampicin, clofazimine, and dapsone. The second was a six-month treatment for paucibacillary (PB or tuberculoid) cases, using rifampicin and dapsone. At the First International Conference on the Elimination of Leprosy as a Public Health Problem, held in Hanoi the next year, the global strategy was endorsed and funds provided to WHO for the procurement and supply of MDT to all endemic countries.
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| Since 1995, WHO has supplied all endemic countries with free MDT in blister packs, supplied through Ministries of Health. This free provision was extended in 2000, and again in 2005, and will run until at least the end of 2010. At the national level, non-government organisations (NGOs) affiliated to the national programme will continue to be provided with an appropriate free supply of this MDT by the government.
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| MDT remains highly effective and patients are no longer infectious after the first monthly dose. It is safe and easy to use under field conditions due to its presentation in calendar blister packs. [[Relapse]] rates remain low, and there is no known [[Antibiotic resistance|resistance]] to the combined drugs. The Seventh WHO Expert Committee on Leprosy, <ref name=WHO_1998>{{cite web | title = Seventh WHO Expert Committee on Leprosy| work = WHO Technical Report Series 874 | publisher = WHO | date = 1998 | url = http://www.who.int/lep/resources/expert/en/index.html | accessdate = 2007-03-24}}</ref> reporting in 1997, concluded that the MB duration of treatment—then standing at 24 months—could safely be shortened to 12 months "without significantly compromising its efficacy."
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| Persistent obstacles to the elimination of the disease include improving detection, educating patients and the population about its cause, and fighting social taboos about a disease for which patients have historically been considered "unclean" or "cursed by God" as outcasts. Where taboos are strong, patients may be forced to hide their condition (and avoid seeking treatment) to avoid discrimination. The lack of awareness about Hansen's disease can lead people to falsely believe that the disease is highly contagious and incurable.
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| [[Image:MDTRegimens.jpg|thumb|left|200px|MDT anti-leprosy drugs: standard regimens]]
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| [[Image:Blisters01.jpg|thumb|left|200px|MDT patient packs and blisters]]
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