Small cell carcinoma of the lung pathophysiology: Difference between revisions
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==Molecular Abnormalities== | ==Molecular Abnormalities== | ||
A mutation in [[p53]] is found in 75% to 100% of cases of small cell carcinoma. Other molecular abnormalities have been described that influence in the development of small cell carcinoma, such as [[MYC]] amplification, [[BCL2]] expression, [[RB1]] deletion (loss of RB1 protein), [[VEGF]] ([[vascular endothelial growth factor]]) expression, [[c-kit]]/[[Stem cell factor|SCFR]] ([[stem cell factor]] receptor) coexpression.<ref>{{Cite journal | A mutation in [[p53]] is found in 75% to 100% of cases of small cell carcinoma. Other molecular abnormalities have been described that influence in the development of small cell carcinoma, such as [[Myc|MYC]] amplification, [[Bcl-2|BCL2]] expression, [[RB1]] deletion (loss of RB1 protein), [[VEGF]] ([[vascular endothelial growth factor]]) expression, [[c-kit]]/[[Stem cell factor|SCFR]] ([[stem cell factor]] receptor) coexpression.<ref>{{Cite journal | ||
| author = [[Grace K. Dy]] & [[Alex A. Adjei]] | | author = [[Grace K. Dy]] & [[Alex A. Adjei]] | ||
| title = Novel targets for lung cancer therapy: part I | | title = Novel targets for lung cancer therapy: part I |
Revision as of 16:21, 9 June 2014
Small Cell Carcinoma of the Lung Microchapters |
Differentiating Small Cell Carcinoma of the Lung from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Small cell lung cancer is the most aggressive form of lung cancer. It usually starts in the breathing tubes (bronchi) in the center of the chest. Although the cancer cells are small, they grow very quickly and create large tumors. These tumors often spread rapidly (metastasize) to other parts of the body, including the brain, liver, and bone.
Molecular Abnormalities
A mutation in p53 is found in 75% to 100% of cases of small cell carcinoma. Other molecular abnormalities have been described that influence in the development of small cell carcinoma, such as MYC amplification, BCL2 expression, RB1 deletion (loss of RB1 protein), VEGF (vascular endothelial growth factor) expression, c-kit/SCFR (stem cell factor receptor) coexpression.[1]
Smoking
Gross Pathology
References
- ↑ Grace K. Dy & Alex A. Adjei (2002). "Novel targets for lung cancer therapy: part I". Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 20 (12): 2881–2894. PMID 12065566. Unknown parameter
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