WBR0141: Difference between revisions
Jump to navigation
Jump to search
Rim Halaby (talk | contribs) No edit summary |
No edit summary |
||
| Line 21: | Line 21: | ||
|SubCategory=General Principles | |SubCategory=General Principles | ||
|Prompt=Neutrophils are critically involved in the inflammation process. The process of leukocyte movement from the blood to the tissues through the blood vessels is known as extravasation, and can be divided up into a number of broad steps. Which of the signaling mediators is involved in the migration of the neutrophils across the endothelial cells? | |Prompt=Neutrophils are critically involved in the inflammation process. The process of leukocyte movement from the blood to the tissues through the blood vessels is known as extravasation, and can be divided up into a number of broad steps. Which of the signaling mediators is involved in the migration of the neutrophils across the endothelial cells? | ||
|AnswerA=E selectin and P selectin | |AnswerA=E selectin and P selectin | ||
|AnswerAExp=[[E selectin]] and P selectin are involved in the rolling phase. | |AnswerAExp=[[E selectin]] and P selectin are involved in the rolling phase. | ||
| Line 30: | Line 29: | ||
|AnswerD=C5a | |AnswerD=C5a | ||
|AnswerDExp=[[C5]] a is involved in the migration of leykocytes through the interstitum towards the site of inflammation. | |AnswerDExp=[[C5]] a is involved in the migration of leykocytes through the interstitum towards the site of inflammation. | ||
|AnswerE= | |AnswerE=Interleukin 8 | ||
|AnswerEExp=[[Interleukin]] 8 is involved in the migration of [[leukocytes]] through the interstitium towards the site of [[inflammation]]. | |AnswerEExp=[[Interleukin]] 8 is involved in the migration of [[leukocytes]] through the interstitium towards the site of [[inflammation]]. | ||
|EducationalObjectives=[[Inflammation]] involves several steps including the rolling phase of the [[neutrophils]], their binding to the [[endothelium]], [[diapedesis]] and migration to the site of inflammation. [[PECAM 1]] is involved in diapedesis, which is the migration of the leukocytes across the endothelial cells. | |||
|References=First Aid 2014 page 224 | |||
|RightAnswer=C | |RightAnswer=C | ||
|WBRKeyword=Inflammation, Diapedesis, Leukocyte, Leukocyte adhesion, Endothelium, Endothelial cell | |||
|Approved=No | |Approved=No | ||
}} | }} | ||
Revision as of 22:35, 14 March 2014
| Author | [[PageAuthor::Rim Halaby, M.D. [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Immunology |
| Sub Category | SubCategory::General Principles |
| Prompt | [[Prompt::Neutrophils are critically involved in the inflammation process. The process of leukocyte movement from the blood to the tissues through the blood vessels is known as extravasation, and can be divided up into a number of broad steps. Which of the signaling mediators is involved in the migration of the neutrophils across the endothelial cells?]] |
| Answer A | AnswerA::E selectin and P selectin |
| Answer A Explanation | [[AnswerAExp::E selectin and P selectin are involved in the rolling phase.]] |
| Answer B | AnswerB::ICAM 1 |
| Answer B Explanation | [[AnswerBExp::ICAM-1 is involved in the tight binding of neutrophils to the endothelium.]] |
| Answer C | AnswerC::PECAM 1 |
| Answer C Explanation | [[AnswerCExp::PECAM-1 is involved in diapedesis, which is the migration of the leukocytes across the endothelial cells.]] |
| Answer D | AnswerD::C5a |
| Answer D Explanation | [[AnswerDExp::C5 a is involved in the migration of leykocytes through the interstitum towards the site of inflammation.]] |
| Answer E | AnswerE::Interleukin 8 |
| Answer E Explanation | [[AnswerEExp::Interleukin 8 is involved in the migration of leukocytes through the interstitium towards the site of inflammation.]] |
| Right Answer | RightAnswer::C |
| Explanation | [[Explanation:: Educational Objective: Inflammation involves several steps including the rolling phase of the neutrophils, their binding to the endothelium, diapedesis and migration to the site of inflammation. PECAM 1 is involved in diapedesis, which is the migration of the leukocytes across the endothelial cells. |
| Approved | Approved::No |
| Keyword | WBRKeyword::Inflammation, WBRKeyword::Diapedesis, WBRKeyword::Leukocyte, WBRKeyword::Leukocyte adhesion, WBRKeyword::Endothelium, WBRKeyword::Endothelial cell |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |