Cefditoren overdosage: Difference between revisions

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==Overdosage==


 
Information on cefditoren pivoxil overdosage in humans is not available. However, with other ß-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions. Hemodialysis may aid in the removal of cefditoren from the body, particularly if renal function is compromised (30% reduction of plasma concentrations following 4 hours of hemodialysis). Treat overdosage symptomatically and institute supportive measures as required.
<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = SPECTRACEF (CEFDITOREN PIVOXIL) TABLET, FILM COATED SPECTRACEF (CEFDITOREN PIVOXIL) TABLET, FILM COATED [CORNERSTONE THERAPEUTICS INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f732ed2f-48b9-4331-87ab-81b5fbe728aa | publisher =  | date =  | accessdate = }}</ref>
In acute animal toxicity studies, cefditoren pivoxil when tested at the limit oral doses of 5100 mg/kg in rats and up to 2000 mg/kg in dogs did not exhibit any health effects of concern. Certain effects, such as diarrhea and soft stool lasting for a few days were observed in some animals as expected with most oral antibiotics due to inhibition of intestinal microflora.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = SPECTRACEF (CEFDITOREN PIVOXIL) TABLET, FILM COATED SPECTRACEF (CEFDITOREN PIVOXIL) TABLET, FILM COATED [CORNERSTONE THERAPEUTICS INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f732ed2f-48b9-4331-87ab-81b5fbe728aa | publisher =  | date =  | accessdate = }}</ref>


==References==
==References==

Revision as of 01:38, 6 January 2014

Cefditoren
SPECTRACEF® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overdosage

Information on cefditoren pivoxil overdosage in humans is not available. However, with other ß-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions. Hemodialysis may aid in the removal of cefditoren from the body, particularly if renal function is compromised (30% reduction of plasma concentrations following 4 hours of hemodialysis). Treat overdosage symptomatically and institute supportive measures as required. In acute animal toxicity studies, cefditoren pivoxil when tested at the limit oral doses of 5100 mg/kg in rats and up to 2000 mg/kg in dogs did not exhibit any health effects of concern. Certain effects, such as diarrhea and soft stool lasting for a few days were observed in some animals as expected with most oral antibiotics due to inhibition of intestinal microflora.[1]

References

  1. "SPECTRACEF (CEFDITOREN PIVOXIL) TABLET, FILM COATED SPECTRACEF (CEFDITOREN PIVOXIL) TABLET, FILM COATED [CORNERSTONE THERAPEUTICS INC.]".

Adapted from the FDA Package Insert.