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(Created page with "{{WBRQuestion |QuestionAuthor=William J Gibson |ExamType=USMLE Step 1 |Prompt=A 5 year old boy from rural Africa has recently immigrated to the United States with his family. ...") |
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|QuestionAuthor=William J Gibson | |QuestionAuthor=William J Gibson | ||
|ExamType=USMLE Step 1 | |ExamType=USMLE Step 1 | ||
|MainCategory=Microbiology | |||
|SubCategory=Head and Neck, Neurology, General Principles, Infectious Disease | |||
|MainCategory=Microbiology | |||
|SubCategory=Head and Neck, Neurology, General Principles, Infectious Disease | |||
|MainCategory=Microbiology | |||
|SubCategory=Head and Neck, Neurology, General Principles, Infectious Disease | |||
|MainCategory=Microbiology | |||
|MainCategory=Microbiology | |||
|SubCategory=Head and Neck, Neurology, General Principles, Infectious Disease | |||
|MainCategory=Microbiology | |||
|SubCategory=Head and Neck, Neurology, General Principles, Infectious Disease | |||
|MainCategory=Microbiology | |||
|SubCategory=Head and Neck, Neurology, General Principles, Infectious Disease | |||
|MainCategory=Microbiology | |||
|SubCategory=Head and Neck, Neurology, General Principles, Infectious Disease | |||
|MainCategory=Microbiology | |||
|MainCategory=Microbiology | |||
|SubCategory=Head and Neck, Neurology, General Principles, Infectious Disease | |||
|Prompt=A 5 year old boy from rural Africa has recently immigrated to the United States with his family. He presents to your office with a fever of 100.7 F, fatigue, and severe pharyngitis. Physical exam reveals marked cervical lymphadenopathy, and pseudomembranes in the throat. A throat swab is performed which reveals gram positive bacilli. What is the mechanism of action of the toxin produced by the causative organism? | |Prompt=A 5 year old boy from rural Africa has recently immigrated to the United States with his family. He presents to your office with a fever of 100.7 F, fatigue, and severe pharyngitis. Physical exam reveals marked cervical lymphadenopathy, and pseudomembranes in the throat. A throat swab is performed which reveals gram positive bacilli. What is the mechanism of action of the toxin produced by the causative organism? | ||
|Explanation=This patient is suffering from an infection by Corynebacterium Diptheriae, a gram positive rod which has mostly been eradicated in the developed world through vaccination. Diptheria causes upper respiratory tract infections with sore throat and low-grade fever. The hallmark of this infection is an adherent true membrane on the tonsils referred to as pseudomembranes. | |Explanation=This patient is suffering from an infection by Corynebacterium Diptheriae, a gram positive rod which has mostly been eradicated in the developed world through vaccination. Diptheria causes upper respiratory tract infections with sore throat and low-grade fever. The hallmark of this infection is an adherent true membrane on the tonsils referred to as pseudomembranes. |
Revision as of 00:46, 2 July 2013
Author | PageAuthor::William J Gibson |
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Exam Type | ExamType::USMLE Step 1 |
Main Category | MainCategory::Microbiology |
Sub Category | SubCategory::Head and Neck, SubCategory::Neurology, SubCategory::General Principles, SubCategory::Infectious Disease |
Prompt | [[Prompt::A 5 year old boy from rural Africa has recently immigrated to the United States with his family. He presents to your office with a fever of 100.7 F, fatigue, and severe pharyngitis. Physical exam reveals marked cervical lymphadenopathy, and pseudomembranes in the throat. A throat swab is performed which reveals gram positive bacilli. What is the mechanism of action of the toxin produced by the causative organism?]] |
Answer A | AnswerA::Inactivate 60S ribsosome by cleaving rRNA |
Answer A Explanation | AnswerAExp::Incorrect - This is the mechanism of the toxin produced by Shigella and EHEC. |
Answer B | AnswerB::Activates adenylate cyclase by stimulating Gs |
Answer B Explanation | AnswerBExp::Incorrect - This is the mechanism of the toxin produced by Vibrio Cholera |
Answer C | AnswerC::Activates adenylate cyclase by disabling Gi |
Answer C Explanation | AnswerCExp::Incorrect - This is the mechanism of the toxin produced by Bordetella Pertusis. |
Answer D | AnswerD::Cleaves SNARE protein |
Answer D Explanation | AnswerDExp::Incorrect - This is the mechanism of Botulinum and Tetanus toxin, which disables neurotransmitter release at the synaptic cleft. |
Answer E | AnswerE::Inactivate EF-2 |
Answer E Explanation | AnswerEExp::Correct - See Explanation |
Right Answer | RightAnswer::E |
Explanation | [[Explanation::This patient is suffering from an infection by Corynebacterium Diptheriae, a gram positive rod which has mostly been eradicated in the developed world through vaccination. Diptheria causes upper respiratory tract infections with sore throat and low-grade fever. The hallmark of this infection is an adherent true membrane on the tonsils referred to as pseudomembranes.
References: First Aid 2012 page 152.
Tags: #Microbiology #Pathophysiology |
Approved | Approved::Yes |
Keyword | |
Linked Question | Linked:: |
Order in Linked Questions | LinkedOrder:: |