CES2: Difference between revisions

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(moved CES2 to Carboxylesterase 2: recommended UniProt name for this enzyme)
 
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#REDIRECT [[Carboxylesterase 2]]
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Carboxylesterase 2 (intestine, liver)
| HGNCid = 1864
| Symbol = CES2
| AltSymbols =; CE-2; CES2A1; PCE-2; iCE
| OMIM = 605278
| ECnumber = 
| Homologene = 55787
| MGIid = 3648740
| GeneAtlas_image1 = PBB_GE_CES2_209667_at_tn.png
| GeneAtlas_image2 = PBB_GE_CES2_209668_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CES2_213509_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004759 |text = carboxylesterase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0009056 |text = catabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8824
    | Hs_Ensembl = ENSG00000172831
    | Hs_RefseqProtein = NP_003860
    | Hs_RefseqmRNA = NM_003869
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 65525848
    | Hs_GenLoc_end = 65536473
    | Hs_Uniprot = O00748
    | Mm_EntrezGene = 436059
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_488149
    | Mm_RefseqProtein = XP_488149
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
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'''Carboxylesterase 2 (intestine, liver)''', also known as '''CES2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8824| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8824| accessdate = }}</ref>
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Schwer H, Langmann T, Daig R, ''et al.'' |title=Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 1 |pages= 117-20 |year= 1997 |pmid= 9144407 |doi= 10.1006/bbrc.1997.6413 }}
*{{cite journal  | author=Pindel EV, Kedishvili NY, Abraham TL, ''et al.'' |title=Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14769-75 |year= 1997 |pmid= 9169443 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Yan B, Matoney L, Yang D |title=Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms. |journal=Placenta |volume=20 |issue= 7 |pages= 599-607 |year= 1999 |pmid= 10452915 |doi= 10.1053/plac.1999.0407 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | author=Chagnon P, Michaud J, Mitchell G, ''et al.'' |title=A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1443-9 |year= 2003 |pmid= 12417987 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Saito S, Iida A, Sekine A, ''et al.'' |title=Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. |journal=J. Hum. Genet. |volume=48 |issue= 5 |pages= 249-70 |year= 2003 |pmid= 12721789 |doi= 10.1007/s10038-003-0021-7 }}
*{{cite journal  | author=Wu MH, Chen P, Remo BF, ''et al.'' |title=Characterization of multiple promoters in the human carboxylesterase 2 gene. |journal=Pharmacogenetics |volume=13 |issue= 7 |pages= 425-35 |year= 2004 |pmid= 12835618 |doi= 10.1097/01.fpc.0000054103.48725.db }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Marsh S, Xiao M, Yu J, ''et al.'' |title=Pharmacogenomic assessment of carboxylesterases 1 and 2. |journal=Genomics |volume=84 |issue= 4 |pages= 661-8 |year= 2005 |pmid= 15475243 |doi= 10.1016/j.ygeno.2004.07.008 }}
*{{cite journal  | author=Wu MH, Chen P, Wu X, ''et al.'' |title=Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene. |journal=Pharmacogenetics |volume=14 |issue= 9 |pages= 595-605 |year= 2005 |pmid= 15475733 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Charasson V, Bellott R, Meynard D, ''et al.'' |title=Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. |journal=Clin. Pharmacol. Ther. |volume=76 |issue= 6 |pages= 528-35 |year= 2005 |pmid= 15592324 |doi= 10.1016/j.clpt.2004.08.007 }}
*{{cite journal  | author=Kim SR, Nakamura T, Saito Y, ''et al.'' |title=Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2). |journal=Drug Metab. Pharmacokinet. |volume=18 |issue= 5 |pages= 327-32 |year= 2005 |pmid= 15618752 |doi=  }}
*{{cite journal  | author=Fox CA, Sapinoso LM, Zhang H, ''et al.'' |title=Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas. |journal=Neoplasia |volume=7 |issue= 4 |pages= 407-16 |year= 2005 |pmid= 15967118 |doi=  }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
{{refend}}
 
{{protein-stub}}
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Revision as of 15:04, 4 September 2012


Carboxylesterase 2 (intestine, liver)
Identifiers
Symbols CES2 ; CE-2; CES2A1; PCE-2; iCE
External IDs Template:OMIM5 Template:MGI HomoloGene: 55787
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Carboxylesterase 2 (intestine, liver), also known as CES2, is a human gene.[1]

Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Schwer H, Langmann T, Daig R; et al. (1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver". Biochem. Biophys. Res. Commun. 233 (1): 117–20. doi:10.1006/bbrc.1997.6413. PMID 9144407.
  • Pindel EV, Kedishvili NY, Abraham TL; et al. (1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". J. Biol. Chem. 272 (23): 14769–75. PMID 9169443.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Yan B, Matoney L, Yang D (1999). "Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms". Placenta. 20 (7): 599–607. doi:10.1053/plac.1999.0407. PMID 10452915.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
  • Chagnon P, Michaud J, Mitchell G; et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. PMID 12417987.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Saito S, Iida A, Sekine A; et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". J. Hum. Genet. 48 (5): 249–70. doi:10.1007/s10038-003-0021-7. PMID 12721789.
  • Wu MH, Chen P, Remo BF; et al. (2004). "Characterization of multiple promoters in the human carboxylesterase 2 gene". Pharmacogenetics. 13 (7): 425–35. doi:10.1097/01.fpc.0000054103.48725.db. PMID 12835618.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Marsh S, Xiao M, Yu J; et al. (2005). "Pharmacogenomic assessment of carboxylesterases 1 and 2". Genomics. 84 (4): 661–8. doi:10.1016/j.ygeno.2004.07.008. PMID 15475243.
  • Wu MH, Chen P, Wu X; et al. (2005). "Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene". Pharmacogenetics. 14 (9): 595–605. PMID 15475733.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
  • Charasson V, Bellott R, Meynard D; et al. (2005). "Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38". Clin. Pharmacol. Ther. 76 (6): 528–35. doi:10.1016/j.clpt.2004.08.007. PMID 15592324.
  • Kim SR, Nakamura T, Saito Y; et al. (2005). "Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2)". Drug Metab. Pharmacokinet. 18 (5): 327–32. PMID 15618752.
  • Fox CA, Sapinoso LM, Zhang H; et al. (2005). "Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas". Neoplasia. 7 (4): 407–16. PMID 15967118.
  • Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.

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