Chlortalidone

Chlortalidone

Clinical data
Pregnancy category	C (Au), B (U.S.)
Routes of administration	Oral
ATC code	C03BA04 (WHO)
Legal status
Legal status	POM (UK)
Pharmacokinetic data
Protein binding	75%
Elimination half-life	40 hours
Excretion	Renal
Identifiers
IUPAC name 2-chloro-5-(1-hydroxy-3-oxo-1,2-dihydroisoindol-1-yl)- benzenesulfonamide
CAS Number	77-36-1
PubChem CID	2732
DrugBank	APRD00127
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C14H11ClN2O4S
Molar mass	338.767 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Chlortalidone (formerly spelled chlorthalidone in the UK, and still so called in the United States) is a drug used to treat hypertension. It is described as a thiazide diuretic (or, rather, a thiazide-like diuretic because it acts similarly to the thiazides but does not contain the benzothiadiazine molecular structure).

It is also available in the UK as a combination product with the beta blocker atenolol as Co-tenidone.